Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.40 |
| ▸ | TTK | P33981 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.40 |
| ▸ | CDK17 | Q00537 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23368031 | 0.89 | CYP17A1 (0.41) | LMNAABL1MAPK14KDRRAF1 | |
| SCHEMBL21612809 | 0.79 | CYP17A1 (0.42) | LMNAABL1MAPK14KDRRAF1 | |
| SCHEMBL23355378 | 0.79 | LMNA (0.37) | LMNAABL1KDRKITPDGFRA | |
| SCHEMBL29834712 | 0.79 | KDR (0.41) | LMNAABL1MAPK14KDRRAF1 | |
| SCHEMBL29834629 | 0.76 | CYP17A1 (0.42) | LMNAABL1MAPK14KDRRAF1 | |
| SCHEMBL23355406 | 0.76 | SCN9A (0.36) | LMNAABL1MAPK14KDRBRAF | |
| SCHEMBL21612852 | 0.75 | ABCB1 (0.44) | LMNAKDRBRAFFLT1SMN1; SMN2 | |
| SCHEMBL29834721 | 0.75 | ABCB1 (0.43) | LMNAABL1MAPK14KDRRAF1 | |
| SCHEMBL23355472 | 0.75 | CA1 (0.35) | LMNAABL1MAPK14KDRKIT | |
| SCHEMBL23355431 | 0.75 | RAB9A (0.51) | LMNASMN1; SMN2RAB9AANO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822263-A1 | BIARYL ETHER-TYPE QUINAZOLINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2021-05-19 | — | — | EP | disclosed |