Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 7/20 | 0.46 |
| ▸ | MST1R | Q04912 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28512289 | 0.89 | MET (0.47) | KDRPDGFRASRCTGFBR1MET | |
| SCHEMBL1549776 | 0.85 | MET (0.48) | KDRPDGFRASRCTGFBR1MET | |
| SCHEMBL1876626 | 0.84 | AXL (0.54) | KDRPDGFRAMETAXL | |
| SCHEMBL1549363 | 0.84 | MET (0.43) | KDRPDGFRASRCTGFBR1MET | |
| SCHEMBL28907136 | 0.83 | MET (0.48) | KDRPDGFRAMETMST1RAXL | |
| SCHEMBL30713842 | 0.83 | MET (0.55) | KDRPDGFRAMETMST1RAXL | |
| SCHEMBL371803 | 0.83 | MET (0.55) | KDRPDGFRAMETMST1RAXL | |
| SCHEMBL4483017 | 0.83 | MET (0.55) | KDRPDGFRAMETMST1RAXL | |
| SCHEMBL25233743 | 0.82 | KDR (0.48) | KDRPDGFRAMETMST1RAXL | |
| SCHEMBL30465509 | 0.82 | KDR (0.48) | KDRPDGFRAMETMST1RAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2210607-B1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | EXELIXIS INC (US) | 2011-08-17 | — | — | EP | disclosed |