Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2344965 | 0.82 | RECQL (0.37) | EPHX1KEAP1NFE2L2SMN1; SMN2SSTR4 | |
| SCHEMBL11229398 | 0.80 | HSD17B10 (0.40) | EPHX1KEAP1NFE2L2SMN1; SMN2SSTR4 | |
| SCHEMBL28107685 | 0.80 | CYP2D6 (0.41) | EPHX1KEAP1NFE2L2SMN1; SMN2SSTR4 | |
| SCHEMBL3147437 | 0.78 | SSTR4 (0.36) | EPHX1KEAP1NFE2L2SMN1; SMN2SSTR4 | |
| SCHEMBL28103582 | 0.78 | EPHX1 (0.35) | EPHX1KEAP1NFE2L2SSTR4CHRM2 | |
| SCHEMBL27489829 | 0.78 | KDM4E (0.39) | EPHX1KEAP1NFE2L2SMN1; SMN2SSTR4 | |
| SCHEMBL28785379 | 0.77 | EPHX1 (0.33) | EPHX1KEAP1NFE2L2SMN1; SMN2SSTR4 | |
| SCHEMBL432459 | 0.76 | CCR2 (0.37) | EPHX1KEAP1NFE2L2SMN1; SMN2SSTR4 | |
| SCHEMBL3271255 | 0.76 | CYP1A2 (0.39) | EPHX1SSTR4CHRM2CHRM4CHRM1 | |
| SCHEMBL11323557 | 0.74 | ALDH1A1 (0.40) | EPHX1SMN1; SMN2SSTR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247609-B2 | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors | Pharamleads (FR) | 2012-08-21 | — | — | US | disclosed |
| EP-1940818-B1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | PHARMALEADS (FR) | 2011-08-24 | — | — | EP | disclosed |
| EP-1940818-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | Pharmaleads (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007048787-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | PHARMALEADS (FR) | 2007-05-03 | — | — | WO | disclosed |