⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL25335734 | 0.86 | — | — | |
| Acetic Acid SCHEMBL2893176 | 0.84 | FFAR3 (0.35) | — | |
| SCHEMBL31036738 | 0.82 | — | — | |
| SCHEMBL235810 | 0.69 | — | — | |
| SCHEMBL7094129 | 0.69 | — | — | |
| SCHEMBL1572948 | 0.67 | — | — | |
| SCHEMBL19987966 | 0.67 | — | — | |
| SCHEMBL236785 | 0.65 | FDPS (0.35) | — | |
| SCHEMBL24916374 | 0.63 | — | — | |
| SCHEMBL7095545 | 0.63 | MAPT (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260043009-A1 | ENGINEERED GALACTOSE OXIDASE VARIANT ENZYMES | CODEXIS, INC. (US) | 2026-02-12 | — | — | US | disclosed |
| US-12480099-B2 | Engineered galactose oxidase variant enzymes | CODEXIS, INC. (US) | 2025-11-25 | — | — | US | disclosed |
| US-20250215404-A1 | ENGINEERED ACETATE KINASE VARIANT ENZYMES | CODEXIS, INC. | 2025-07-03 | — | — | US | disclosed |
| CN-112673097-B | Engineered galactose oxidase variant enzymes | 科德克希思公司 | 2025-05-06 | — | — | CN | disclosed |
| US-12275962-B2 | Engineered acetate kinase variant enzymes | CODEXIS, INC. (US) | 2025-04-15 | — | — | US | disclosed |
| CN-118995846-A | Enzymatic synthesis of 4' -ethynyl nucleoside analogues | 默沙东有限责任公司 | 2024-11-22 | — | — | CN | disclosed |
| US-20240301460-A1 | ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGS | MERCK SHARP & DOHME LLC (US) | 2024-09-12 | — | — | US | disclosed |
| US-20240287474-A1 | ENGINEERED GALACTOSE OXIDASE VARIANT ENZYMES | CODEXIS, INC. (US) | 2024-08-29 | — | — | US | disclosed |
| CN-112996511-B | Enzymatic synthesis of 4' -ethynyl nucleoside analogues | 默沙东有限责任公司 | 2024-08-09 | — | — | CN | disclosed |
| US-12037623-B2 | Enzymatic synthesis of 4′-ethynyl nucleoside analogs | Merck, Sharp & Dohme LLC (US) | 2024-07-16 | — | — | US | disclosed |
| US-20230026007-A1 | ENGINEERED GALACTOSE OXIDASE VARIANT ENZYMES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-01-26 | — | — | US | disclosed |
| US-11466259-B2 | Engineered galactose oxidase variant enzymes | CODEXIS, INC. (US) | 2022-10-11 | — | — | US | disclosed |
| US-20220251523-A1 | ENGINEERED ACETATE KINASE VARIANT ENZYMES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2022-08-11 | — | — | US | disclosed |
| US-20220228184-A1 | ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGS | MERCK SHARP & DOHME CORP. (US) | 2022-07-21 | — | — | US | disclosed |
| WO-2022076263-A1 | ENGINEERED GALACTOSE OXIDASE VARIANT ENZYMES | CODEXIS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |
| CN-112996511-A | Enzymatic synthesis of 4' -ethynyl nucleoside analogs | 默沙东公司 | 2021-06-18 | — | — | CN | disclosed |
| EP-3821000-A1 | ENGINEERED GALACTOSE OXIDASE VARIANT ENZYMES | Codexis, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |
| EP-3820473-A1 | ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGS | Merck Sharp & Dohme Corp. (US) | 2021-05-19 | — | — | EP | disclosed |
| CN-112673097-A | Engineered galactose oxidase variant enzymes | 科德克希思公司 | 2021-04-16 | — | — | CN | disclosed |
| CN-101573033-A | Heterocyclyl-substituted anti-hypercholesterolemic compounds | MERCK & CO INC (US) | 2009-11-04 | — | — | CN | disclosed |