Sugi Predict

Sugi Predict / Compounds / SCHEMBL23356901

SCHEMBL23356901

SCHEMBL23356901

Cc1ccc(S(=O)(=O)n2ncc3cc(C[C@@H](CN4C(=O)c5ccccc5C4=O)N(C)C)ccc32)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ OPRD1 P41143 7/20 0.59
▸ OPRK1 P41145 1/20 0.57
▸ OPRM1 P35372 5/20 0.54
▸ PABPC1 P11940 1/20 0.36
▸ ALOX15 P16050 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ CLTC Q00610 1/20 0.36
▸ PDE10A Q9Y233 1/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ SLC9A1 P19634 1/20 0.34
▸ CA12 O43570 1/20 0.34
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ CA9 Q16790 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ LMNA P02545 1/20 0.33
▸ MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23356903 1.00 OPRD1 (0.59) OPRD1OPRK1OPRM1PABPC1ALOX15
SCHEMBL23356831 0.88 OPRD1 (0.54) OPRD1OPRK1OPRM1PABPC1ALOX15
SCHEMBL23356834 0.88 OPRD1 (0.54) OPRD1OPRK1OPRM1PABPC1ALOX15
Hydrochloric Acid SCHEMBL23357244 0.86 OPRD1 (0.48) OPRD1OPRK1OPRM1PABPC1ALOX15
Hydrochloric Acid SCHEMBL23357246 0.86 OPRD1 (0.48) OPRD1OPRK1OPRM1PABPC1ALOX15
SCHEMBL23356994 0.84 OPRD1 (0.65) OPRD1OPRK1OPRM1ALDH1A1SLC9A1
SCHEMBL23356996 0.84 OPRD1 (0.65) OPRD1OPRK1OPRM1ALDH1A1SLC9A1
SCHEMBL23356942 0.83 OPRD1 (0.53) OPRD1OPRK1OPRM1ALDH1A1KMT2A
SCHEMBL23356944 0.83 OPRD1 (0.53) OPRD1OPRK1OPRM1ALDH1A1KMT2A
SCHEMBL27086851 0.82 OPRM1 (0.51) OPRD1OPRK1OPRM1ALDH1A1SLC9A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112867705-B Opioid receptor modulators and products and methods related thereto 埃皮欧黛公司 2024-08-20 — — CN disclosed
EP-3774722-B1 OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO EPIODYNE INC (US) 2024-07-24 — — EP disclosed
US-11352316-B2 Opioid receptor modulators and products and methods related thereto EPIODYNE, INC. (US) 2022-06-07 — — US disclosed
US-20210163402-A1 OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO EPIODYNE, INC. 2021-06-03 — — US disclosed
US-20210147343-A1 OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO EPIODYNE, INC. 2021-05-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11352316-B2 Opioid receptor modulators and products and methods related thereto OPRM1, OPRD1, OPRK1 OPRD1 2/4885OPRK1 3/4885OPRM1 1/4885
US-20210163402-A1 OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO OPRM1, OPRD1, OPRK1 OPRD1 2/4885OPRK1 3/4885OPRM1 1/4885
US-20210147343-A1 OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO OPRM1, OPRD1, OPRK1 OPRD1 2/4885OPRK1 3/4885OPRM1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.