Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337750 | 1.00 | HTR1A (0.45) | HTR1ASLC6A2SLC6A4SLC6A3ROCK2 | |
| SCHEMBL2339097 | 1.00 | HTR1A (0.45) | HTR1ASLC6A2SLC6A4SLC6A3ROCK2 | |
| SCHEMBL5606643 | 0.89 | ROCK2 (0.42) | HTR1AROCK2DRD2DRD3LMNA | |
| SCHEMBL12295006 | 0.89 | ROCK2 (0.42) | HTR1AROCK2DRD2DRD3LMNA | |
| SCHEMBL1737783 | 0.89 | ROCK2 (0.42) | HTR1AROCK2DRD2DRD3LMNA | |
| SCHEMBL12295002 | 0.89 | ROCK2 (0.42) | HTR1AROCK2DRD2DRD3LMNA | |
| SCHEMBL12295007 | 0.89 | ROCK2 (0.42) | HTR1AROCK2DRD2DRD3LMNA | |
| SCHEMBL5592450 | 0.89 | ROCK2 (0.42) | HTR1AROCK2DRD2DRD3LMNA | |
| SCHEMBL1738324 | 0.88 | HTR1A (0.46) | HTR1ASLC6A2SLC6A4SLC6A3ROCK2 | |
| SCHEMBL6694402 | 0.87 | HTR1A (0.48) | HTR1ASLC6A2SLC6A4SLC6A3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012969-B2 | Radiopharmaceutical for positron emission tomography; imaging brain tissue; labeled serotonin type 1B (5HT1B) receptor ligands | GE HEALTHCARE LIMITED (GB) | 2011-09-06 | — | — | US | disclosed |
| US-8012969-B2 | Radiopharmaceutical for positron emission tomography; imaging brain tissue; labeled serotonin type 1B (5HT1B) receptor ligands | GE HEALTHCARE LIMITED (GB) | 2011-09-06 | — | — | US | disclosed |
| US-8012969-B2 | Radiopharmaceutical for positron emission tomography; imaging brain tissue; labeled serotonin type 1B (5HT1B) receptor ligands | GE HEALTHCARE LIMITED (GB) | 2011-09-06 | — | — | US | disclosed |
| EP-1836164-B1 | 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS | GE HEALTHCARE LTD (GB) | 2011-08-24 | — | — | EP | disclosed |
| EP-1836164-B1 | 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS | GE HEALTHCARE LTD (GB) | 2011-08-24 | — | — | EP | disclosed |
| US-20080206137-A1 | 11C-Labeled Benzyl-Lactam Compounds and Their Use as Imaging Agents | GE HEALTHCARE LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
| US-20080206137-A1 | 11C-Labeled Benzyl-Lactam Compounds and Their Use as Imaging Agents | GE HEALTHCARE LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
| US-20080206137-A1 | 11C-Labeled Benzyl-Lactam Compounds and Their Use as Imaging Agents | GE HEALTHCARE LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
| EP-1836164-A1 | 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS | Pfizer Products Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006075226-A1 | 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS | PFIZER PRODUCTS INC. (US) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080206137-A1 | 11C-Labeled Benzyl-Lactam Compounds and Their Use as Imaging Agents | TMEM14C, QPCT, PAICS | HTR1A 2353/4885SLC6A2 2057/4885SLC6A4 2437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.