Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | HTR3A | P46098 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1738324 | 0.89 | HTR1A (0.46) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL5160777 | 0.87 | FPR2 (0.46) | HTR1ASLC6A2SLC6A4ROCK2FPR1 | |
| SCHEMBL5158577 | 0.87 | FPR2 (0.46) | HTR1ASLC6A2SLC6A4ROCK2FPR1 | |
| SCHEMBL5158579 | 0.87 | FPR2 (0.46) | HTR1ASLC6A2SLC6A4ROCK2FPR1 | |
| SCHEMBL1738622 | 0.87 | HTR1A (0.45) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL2335962 | 0.87 | HTR1A (0.45) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL2337750 | 0.87 | HTR1A (0.45) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL2339097 | 0.87 | HTR1A (0.45) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| Hydrochloric Acid SCHEMBL27460761 | 0.86 | FPR2 (0.45) | HTR1ASLC6A2SLC6A4ROCK2FPR1 | |
| Hydrochloric Acid SCHEMBL6431288 | 0.85 | FPR2 (0.44) | HTR1ASLC6A2SLC6A4ROCK2FPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1113015-B1 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PROD INC (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-1113015-B1 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PROD INC (US) | 2004-09-15 | — | — | EP | disclosed |
| US-20030083337-A1 | Optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PRODUCTS, INC. | 2003-05-01 | — | — | US | disclosed |
| US-20030083337-A1 | Optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PRODUCTS, INC. | 2003-05-01 | — | — | US | disclosed |
| US-20030083337-A1 | Optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PRODUCTS, INC. | 2003-05-01 | — | — | US | disclosed |
| US-20010039280-A1 | Optically active 3-[(2-Piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT 1D receptor selective antagonists | PFIZER PRODUCTS INC. | 2001-11-08 | — | — | US | disclosed |
| US-20010039280-A1 | Optically active 3-[(2-Piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT 1D receptor selective antagonists | PFIZER PRODUCTS INC. | 2001-11-08 | — | — | US | disclosed |
| US-20010039280-A1 | Optically active 3-[(2-Piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT 1D receptor selective antagonists | PFIZER PRODUCTS INC. | 2001-11-08 | — | — | US | disclosed |
| JP-2001187781-A | OPTICALLY ACTIVE 3-[(2-PIPERAZINYLPHENYL) METHYL]-1-[4-(TRIFLUOROMETHYL)PHENYL]-2-PYRROLIDINONE COMPOUND AS 5-HT1D RECEPTOR-SELECTIVE ANTAGONIST | PFIZER PROD INC | 2001-07-10 | — | — | JP | disclosed |
| JP-2001187781-A | OPTICALLY ACTIVE 3-[(2-PIPERAZINYLPHENYL) METHYL]-1-[4-(TRIFLUOROMETHYL)PHENYL]-2-PYRROLIDINONE COMPOUND AS 5-HT1D RECEPTOR-SELECTIVE ANTAGONIST | PFIZER PROD INC | 2001-07-10 | — | — | JP | disclosed |
| EP-1113015-A1 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | Pfizer Products Inc. (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-1113015-A1 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | Pfizer Products Inc. (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-1113015-A1 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | Pfizer Products Inc. (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-1113015-A4 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PROD INC (US) | 2001-03-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039280-A1 | Optically active 3-[(2-Piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT 1D receptor selective antagonists | HTR1D, HTR1A, HTR5A | HTR1A 2/4885SLC6A2 462/4885SLC6A4 86/4885 |
| US-20030083337-A1 | Optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | HTR1D, HTR1A, HTR3D | HTR1A 2/4885SLC6A2 544/4885SLC6A4 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.