Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 11/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.38 |
| ▸ | FABP1 | P07148 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334588 | 0.95 | LPAR1 (0.40) | LPAR1LPAR2LPAR3FFAR1NR1H4 | |
| SCHEMBL2341943 | 0.93 | CYP4F2 (0.39) | LPAR1LPAR2LPAR3FFAR4 | |
| SCHEMBL2338262 | 0.91 | LPAR1 (0.50) | LPAR1LPAR2LPAR3NR1H4FABP1 | |
| SCHEMBL2338119 | 0.89 | ALOX5 (0.40) | LPAR1LPAR2LPAR3FFAR4 | |
| SCHEMBL3704161 | 0.87 | LPAR1 (0.47) | LPAR1LPAR2LPAR3NR1H4FABP1 | |
| SCHEMBL2339543 | 0.87 | LPAR1 (0.42) | LPAR1LPAR2LPAR3 | |
| SCHEMBL2335317 | 0.87 | LPAR1 (0.38) | LPAR1LPAR2LPAR3NR1H4 | |
| SCHEMBL3700609 | 0.86 | LPAR1 (0.46) | LPAR1LPAR2LPAR3NR1H4FABP1 | |
| SCHEMBL2336634 | 0.85 | LPAR1 (0.43) | LPAR1LPAR2LPAR3 | |
| SCHEMBL1247211 | 0.85 | FFAR4 (0.42) | FFAR1NR1H4FFAR4FABP1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | claimed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |