Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.42 |
| ▸ | LIFR | P42702 | 1/20 | 0.42 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708502 | 0.95 | IP6K1 (0.40) | NR1H4LIFRHSD17B13IP6K1IP6K3 | |
| SCHEMBL2335317 | 0.92 | LPAR1 (0.38) | NR1H4IP6K1IP6K3IP6K2LMNA | |
| SCHEMBL3706744 | 0.90 | IP6K1 (0.43) | NR1H4IP6K1IP6K3IP6K2LMNA | |
| SCHEMBL3712570 | 0.90 | CYP2C9 (0.36) | NR1H4IP6K1IP6K3IP6K2 | |
| SCHEMBL3705734 | 0.89 | KMO (0.39) | NR1H4LIFRIP6K1IP6K3IP6K2 | |
| SCHEMBL3714244 | 0.89 | KMO (0.41) | NR1H4KMO | |
| SCHEMBL3707271 | 0.88 | PDE4B (0.38) | NR1H4LIFRIP6K1IP6K3IP6K2 | |
| SCHEMBL2335497 | 0.88 | LPAR1 (0.45) | NR1H4 | |
| SCHEMBL3701994 | 0.88 | NR1H4 (0.46) | NR1H4LIFRLMNAMRGPRX4 | |
| SCHEMBL3714395 | 0.87 | NR1H4 (0.40) | NR1H4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |