Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29979625 | 1.00 | PIK3CD (0.36) | PIK3CDPIK3CAPIM1MAP3K12KDM4E | |
| SCHEMBL25147436 | 0.90 | MAPK8 (0.38) | PIM1MAP3K12KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29979598 | 0.90 | PIK3CD (0.43) | PIK3CDPIK3CAMAP3K12KDM4EALDH1A1 | |
| SCHEMBL16692772 | 0.90 | PIK3CD (0.43) | PIK3CDPIK3CAMAP3K12KDM4EALDH1A1 | |
| SCHEMBL29850110 | 0.86 | KDM4E (0.36) | KDM4EALDH1A1SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL29979707 | 0.80 | PIK3CD (0.36) | PIK3CDPIK3CAPIM1MAP3K12ACVR2A | |
| SCHEMBL23365116 | 0.80 | PIK3CD (0.36) | PIK3CDPIK3CAPIM1MAP3K12ACVR2A | |
| SCHEMBL20676296 | 0.80 | CCR1 (0.42) | PIK3CDPIK3CAPIM1MAP3K12KDM4E | |
| SCHEMBL930803 | 0.80 | HDAC4 (0.42) | KDM4EALDH1A1SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL30281430 | 0.80 | HDAC4 (0.42) | KDM4EALDH1A1SMN1; SMN2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230147993-A1 | THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF | CAPULUS THERAPEUTICS, LLC | 2023-05-11 | — | — | US | disclosed |
| US-20230147993-A1 | THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF | CAPULUS THERAPEUTICS, LLC | 2023-05-11 | — | — | US | disclosed |
| US-20230147993-A1 | THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF | CAPULUS THERAPEUTICS, LLC | 2023-05-11 | — | — | US | disclosed |
| EP-4058016-A1 | THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF | Capulus Therapeutics, LLC (US) | 2022-09-21 | — | — | EP | disclosed |
| WO-2021097123-A1 | THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF | CAPULUS THERAPEUTICS, LLC (US) | 2021-05-20 | — | — | WO | disclosed |
| WO-2021097123-A1 | THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF | CAPULUS THERAPEUTICS, LLC (US) | 2021-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230147993-A1 | THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF | SREBF1, SREBF2, FABP1 | PIK3CD 2348/4885PIK3CA 1862/4885PIM1 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.