Sugi Predict

Sugi Predict / Compounds / SCHEMBL930803

SCHEMBL930803

SCHEMBL930803

Brc1ccnc(C2CC2)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC4 P56524 4/20 0.42
▸ HDAC3 O15379 1/20 0.42
▸ HDAC7 Q8WUI4 1/20 0.42
▸ HDAC8 Q9BY41 1/20 0.42
▸ HDAC6 Q9UBN7 1/20 0.42
▸ HDAC9 Q9UKV0 1/20 0.42
▸ HDAC5 Q9UQL6 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ ADORA2A P29274 3/20 0.39
▸ ADORA1 P30542 3/20 0.39
▸ CYP17A1 P05093 1/20 0.35
▸ CHRNA7 P36544 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ PROKR1 Q8TCW9 1/20 0.35
▸ TLR9 Q9NR96 1/20 0.32
▸ TLR8 Q9NR97 1/20 0.32
▸ TLR7 Q9NYK1 1/20 0.32
▸ CYP1A2 P05177 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30281430 1.00 HDAC4 (0.42) HDAC4HDAC3HDAC7HDAC8HDAC6
SCHEMBL28046519 0.92 CHRNA7 (0.42) HDAC4HDAC3HDAC7HDAC8HDAC6
Hydrochloric Acid SCHEMBL28983678 0.91 HDAC4 (0.38) HDAC4HDAC3HDAC7HDAC8HDAC6
SCHEMBL29979598 0.87 PIK3CD (0.43) HDAC4HDAC3HDAC7HDAC8HDAC6
SCHEMBL16692772 0.87 PIK3CD (0.43) HDAC4HDAC3HDAC7HDAC8HDAC6
SCHEMBL29850110 0.82 KDM4E (0.36) HDAC4HDAC3HDAC7HDAC8HDAC6
SCHEMBL23365111 0.80 PIK3CD (0.36) HDAC4HDAC3HDAC7HDAC8HDAC6
SCHEMBL29979625 0.80 PIK3CD (0.36) HDAC4HDAC3HDAC7HDAC8HDAC6
SCHEMBL29006322 0.79 ABL1 (0.53) —
SCHEMBL31032259 0.79 KDM4E (0.34) HDAC4KDM4EALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026088070-A1 COMPOUNDS PFIZER INC. (US) 2026-04-30 — — WO disclosed
US-20260103464-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2026-04-16 — — US disclosed
US-20250325673-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2025-10-23 — — US disclosed
US-12435083-B2 Cyclopropyl-(hetero)aryl-substituted ethylsulphonyl-pyridine derivatives BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2025-10-07 — — US disclosed
US-12435086-B2 Synthesis of heterocyclic compounds PLEXXIKON INC. (US) 2025-10-07 — — US disclosed
EP-4619388-A1 CATHEPSIN L INHIBITORS Biofront Therapeutics (Beijing) Co., Ltd. (CN) 2025-09-24 — — EP disclosed
EP-4613773-A2 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-09-10 — — EP disclosed
EP-3731869-B1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2025-07-23 — — EP disclosed
US-20250059172-A1 INDAZOLE COMPOUND AND PHARMACEUTICAL NIPPON SHINYAKU CO., LTD. (JP) 2025-02-20 — — US disclosed
US-20250000985-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-01-02 — — US disclosed
US-20110071129-A1 SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE MSD K.K. (JP) 2011-03-24 — — US disclosed
US-20110071129-A1 SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE MSD K.K. (JP) 2011-03-24 — — US disclosed
WO-2011002409-A1 5H-PYRROLO[3,4-£>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE ASTRAZENECA AB (SE) 2011-01-06 — — WO disclosed
WO-2011002409-A1 5H-PYRROLO[3,4-£>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE ASTRAZENECA AB (SE) 2011-01-06 — — WO disclosed
US-20100125082-A1 NEW COMPOUNDS 578 ASTRAZENECA AB (SE) 2010-05-20 — — US disclosed
US-20100125082-A1 NEW COMPOUNDS 578 ASTRAZENECA AB (SE) 2010-05-20 — — US disclosed
US-20100125082-A1 NEW COMPOUNDS 578 ASTRAZENECA AB (SE) 2010-05-20 — — US disclosed
WO-2010056196-A1 NEW COMPOUNDS 578 ASTRAZENECA AB (SE) 2010-05-20 — — WO disclosed
WO-2010056196-A1 NEW COMPOUNDS 578 ASTRAZENECA AB (SE) 2010-05-20 — — WO disclosed
WO-2009154132-A1 SPIRODIAMINE-DIARYLKETOXIME DERIVATIVE 萬有製薬株式会社 (JP) 2009-12-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071129-A1 SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE MCHR2, MCHR1, ADRB2 HDAC4 2195/4885HDAC3 1230/4885HDAC7 3085/4885
US-20250325673-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 HDAC4 531/4885HDAC3 73/4885HDAC7 369/4885
US-20100125082-A1 NEW COMPOUNDS 578 PSEN1, PSEN2, BACE1 HDAC4 2728/4885HDAC3 2975/4885HDAC7 1039/4885
US-20250059172-A1 INDAZOLE COMPOUND AND PHARMACEUTICAL MC5R, CYP3A5, PTGIS HDAC4 2340/4885HDAC3 160/4885HDAC7 2581/4885
US-20250000985-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 HDAC4 531/4885HDAC3 73/4885HDAC7 369/4885
US-12435083-B2 Cyclopropyl-(hetero)aryl-substituted ethylsulphonyl-pyridine derivatives CYCS, CYP2E1, CYP1A1 HDAC4 1840/4885HDAC3 965/4885HDAC7 1839/4885
US-20260103464-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES CBR3, CYCS, CBR1 HDAC4 2030/4885HDAC3 313/4885HDAC7 1605/4885
US-12435086-B2 Synthesis of heterocyclic compounds CBR3, CBR1, CCNL2 HDAC4 2482/4885HDAC3 414/4885HDAC7 2288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.