Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24402953 | 0.81 | TP53 (0.44) | TP53SHMT2KMT2AMEN1ALDH1A1 | |
| SCHEMBL4550270 | 0.81 | TP53 (0.44) | TP53SHMT2KMT2AMEN1ALDH1A1 | |
| SCHEMBL24070848 | 0.81 | PHGDH (0.38) | TP53PHGDHMGLLSHMT2KMT2A | |
| SCHEMBL8258141 | 0.80 | HRH3 (0.39) | PHGDHMGLLHRH3POLB | |
| SCHEMBL15680188 | 0.78 | CHRM1 (0.43) | TP53SHMT2KMT2AMEN1ALDH1A1 | |
| SCHEMBL25639671 | 0.77 | PHGDH (0.39) | PHGDHMGLLKMT2AMEN1ALDH1A1 | |
| SCHEMBL4014698 | 0.77 | L3MBTL3 (0.42) | TP53SHMT2ALDH1A1CHRNA7CHRM1 | |
| SCHEMBL12335225 | 0.76 | TP53 (0.49) | TP53SHMT2CHRM1HRH3POLB | |
| SCHEMBL31664986 | 0.74 | CHRM1 (0.46) | TP53ALDH1A1CHRNA7CHRM1HRH3 | |
| SCHEMBL23182433 | 0.74 | TP53 (0.48) | TP53PHGDHMGLLSHMT2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822271-A1 | PYRIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2021-05-19 | — | — | EP | disclosed |