Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 7/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29874053 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2GPR35CYP3A4CYP2D6MEN1 | |
| SCHEMBL23367559 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL29874396 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL29873542 | 0.88 | SMN1; SMN2 (0.41) | SMN1; SMN2GPR35CYP3A4CYP2D6MEN1 | |
| SCHEMBL23384999 | 0.88 | SMN1; SMN2 (0.41) | SMN1; SMN2GPR35CYP3A4CYP2D6MEN1 | |
| SCHEMBL5353016 | 0.83 | MAPT (0.45) | SMN1; SMN2GPR35CYP3A4CYP2D6MEN1 | |
| SCHEMBL5353012 | 0.83 | MAPT (0.45) | SMN1; SMN2GPR35CYP3A4CYP2D6MEN1 | |
| SCHEMBL23354812 | 0.82 | GAA (0.55) | SMN1; SMN2GPR35CYP3A4CYP2D6MEN1 | |
| SCHEMBL23367412 | 0.82 | GAA (0.55) | SMN1; SMN2GPR35CYP3A4CYP2D6MEN1 | |
| SCHEMBL23354810 | 0.82 | GAA (0.55) | SMN1; SMN2GPR35CYP3A4CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230027985-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-01-26 | — | — | US | disclosed |
| EP-3822265-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | Bayer AG (DE) | 2021-05-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230027985-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | ADAMTS7, MMP7, ADAMTS1 | SMN1; SMN2 3772/4885GPR35 1192/4885CYP3A4 3940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.