Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125676 | 1.00 | ALDH1A1 (0.52) | ALDH1A1CES2CES1LMNAL3MBTL1 | |
| SCHEMBL2337504 | 1.00 | ALDH1A1 (0.52) | ALDH1A1CES2CES1LMNAL3MBTL1 | |
| SCHEMBL28260619 | 0.78 | NPC1 (0.64) | ALDH1A1L3MBTL1GAARAB9ANPC1 | |
| SCHEMBL28275739 | 0.78 | NPC1 (0.64) | ALDH1A1L3MBTL1GAARAB9ANPC1 | |
| SCHEMBL11259148 | 0.76 | KDM4E (0.48) | ALDH1A1NAPRTGAARAB9ANPC1 | |
| SCHEMBL11257339 | 0.76 | KDM4E (0.48) | ALDH1A1NAPRTGAARAB9ANPC1 | |
| SCHEMBL1279794 | 0.76 | ALDH1A1 (0.61) | ALDH1A1CES2CES1LMNAL3MBTL1 | |
| SCHEMBL155124 | 0.76 | ALDH1A1 (0.50) | ALDH1A1LMNAL3MBTL1GAARAB9A | |
| SCHEMBL155125 | 0.76 | ALDH1A1 (0.50) | ALDH1A1LMNAL3MBTL1GAARAB9A | |
| SCHEMBL2006799 | 0.75 | CES2 (0.64) | ALDH1A1CES2CES1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358718-A1 | MTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE MTOR/P13K/AKT PATHWAY | Signal Pharmaceuticals, LLC (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010062571-A1 | MTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE MTOR/P13K/AKT PATHWAY | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-06-03 | — | — | WO | disclosed |
| EP-2078016-A2 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051493-A2 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND THEIR USE AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |
| EP-1007525-A1 | AMINOMETYL OXOOXAZOLIDINYL BENZENE DERIVATIVES | ZENECA LIMITED (GB) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999011642-A1 | AMINOMETYL OXOOXAZOLIDINYL BENZENE DERIVATIVES | ZENECA LIMITED (GB) | 1999-03-11 | — | — | WO | disclosed |