Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330399 | 0.82 | SIGMAR1 (0.67) | SIGMAR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20620283 | 0.82 | HPGD (0.45) | MEN1KMT2AHSD11B1ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL20954914 | 0.81 | SIGMAR1 (0.65) | SIGMAR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20620255 | 0.77 | HPGD (0.52) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL30541945 | 0.77 | HPGD (0.52) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL20602918 | 0.76 | HPGD (0.51) | SIGMAR1MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL863907 | 0.71 | SIGMAR1 (0.59) | SIGMAR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL864155 | 0.71 | SIGMAR1 (0.79) | SIGMAR1HDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL11256980 | 0.70 | SIGMAR1 (0.57) | SIGMAR1MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL4226642 | 0.70 | SIGMAR1 (0.61) | SIGMAR1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230355609-A1 | Spirolactone Compounds | QUIXGEN, INC. (US) | 2023-11-09 | — | — | US | disclosed |
| US-11541046-B2 | Spirolactone compounds | QUIXGEN, INC. (US) | 2023-01-03 | — | — | US | disclosed |
| US-20210145822-A1 | Novel Spirolactone Compounds | QUIXGEN, INC. (US) | 2021-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11541046-B2 | Spirolactone compounds | ACACA, AKR1C2, AKR1A1 | SIGMAR1 3037/4885MEN1 1511/4885KMT2A 3481/4885 |
| US-20210145822-A1 | Novel Spirolactone Compounds | ACACA, HSD17B10, AKR1C2 | SIGMAR1 2767/4885MEN1 1916/4885KMT2A 3665/4885 |
| US-20230355609-A1 | Spirolactone Compounds | ACACA, AKR1C2, AKR1A1 | SIGMAR1 3037/4885MEN1 1511/4885KMT2A 3481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.