SCHEMBL233880

SCHEMBL233880

CCNc1ccc(N[SiH3])c(NCC)c1NCC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.39
TSHR P16473 1/20 0.39
RECQL P46063 1/20 0.39
IDO1 P14902 2/20 0.38
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
THRB P10828 1/20 0.34
HPGD P15428 1/20 0.34
HTT P42858 1/20 0.34
GFER P55789 1/20 0.34
PLEC Q15149 1/20 0.34
AOC1 P19801 1/20 0.32
AOC3 Q16853 1/20 0.32
HCAR3 P49019 1/20 0.31
MEN1 O00255 1/20 0.30
USP2 O75604 1/20 0.30
CASP1 P29466 1/20 0.30
BRCA1 P38398 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL233709 0.80 CYP3A4 (0.38) CYP3A4TSHRRECQLIDO1KDM4E
SCHEMBL1954806 0.76 IDO1 (0.55) CYP3A4TSHRRECQLIDO1KDM4E
SCHEMBL8164568 0.73 MEN1 (0.44) CYP3A4TSHRRECQLIDO1KDM4E
SCHEMBL2099502 0.71 CYP3A4 (0.35) CYP3A4TSHRRECQLIDO1KDM4E
SCHEMBL2102937 0.70 MEN1 (0.39) CYP3A4TSHRRECQLIDO1KDM4E
SCHEMBL2104723 0.69 CYP3A4 (0.33) CYP3A4TSHRRECQLIDO1
SCHEMBL2269740 0.69 CYP3A4 (0.33) CYP3A4TSHRRECQLIDO1
SCHEMBL8762491 0.67 CYP3A4 (0.47) CYP3A4TSHRRECQLIDO1ALDH1A1
SCHEMBL2268392 0.66 CYP3A4 (0.32) CYP3A4TSHRRECQLIDO1
SCHEMBL27892583 0.66 PRKCI (0.42) CYP3A4TSHRRECQLIDO1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2360190-B1 SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS USING SAME TOHO TITANIUM CO LTD (JP) 2015-10-14 EP disclosed
US-8426537-B2 Solid catalyst component and catalyst for polymerization of olefins, and process for production of olefin polymers using same TOHO TITANIUM CO., LTD. (JP) 2013-04-23 US disclosed
US-20120004378-A1 SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS USING SAME TOHO TITANIUM CO., LTD (JP) 2012-01-05 US disclosed
EP-2360190-A1 SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS USING SAME Toho Titanium CO., LTD. (JP) 2011-08-24 EP disclosed