Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23390142 | 0.94 | MAPT (0.67) | LIPEMAPTTP53SMN1; SMN2EPHX2 | |
| SCHEMBL23390093 | 0.88 | LIPE (0.54) | LIPEMAPTTP53SMN1; SMN2EPHX2 | |
| SCHEMBL23390133 | 0.84 | LIPE (0.65) | LIPEMAPTTP53SMN1; SMN2EPHX2 | |
| SCHEMBL23390161 | 0.82 | FAAH (0.60) | MAPTTP53SMN1; SMN2EPHX2MEN1 | |
| SCHEMBL23390171 | 0.82 | ALDH1A1 (0.49) | MAPTSMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL23390080 | 0.81 | LIPE (0.54) | LIPEMAPTTP53SMN1; SMN2EPHX2 | |
| SCHEMBL23390083 | 0.81 | LIPE (0.54) | LIPEMAPTTP53SMN1; SMN2EPHX2 | |
| SCHEMBL23390117 | 0.81 | LIPE (0.54) | LIPEMAPTTP53SMN1; SMN2EPHX2 | |
| SCHEMBL23390210 | 0.81 | MAPT (0.48) | LIPEMAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL23390103 | 0.81 | LIPE (0.57) | LIPEMAPTTP53SMN1; SMN2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021102299-A1 | CASPASE 6 INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-05-27 | — | — | WO | disclosed |