SCHEMBL2339031

SCHEMBL2339031

O=CC(Br)c1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.36
AR P10275 9/20 0.35
SCN8A Q9UQD0 1/20 0.34
SLC22A12 Q96S37 1/20 0.34
AKR1C3 P42330 2/20 0.33
AKR1C2 P52895 2/20 0.33
SLC6A4 P31645 1/20 0.33
KMO O15229 2/20 0.33
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
TAS1R2 Q8TE23 1/20 0.33
MPL P40238 1/20 0.33
GRM4 Q14833 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20551738 1.00 KIF11 (0.36) KIF11ARSCN8ASLC22A12AKR1C3
SCHEMBL20551077 0.86 KIF11 (0.46) KIF11
SCHEMBL474259 0.86 KIF11 (0.46) KIF11
SCHEMBL20551343 0.81 KDR (0.41) SCN8AAKR1C3AKR1C2
SCHEMBL1726228 0.81 KDR (0.41) SCN8AAKR1C3AKR1C2
SCHEMBL998053 0.80 CES2 (0.42) AKR1C3AKR1C2
SCHEMBL27664128 0.79 AKR1C3 (0.39) KIF11ARSCN8ASLC22A12AKR1C3
SCHEMBL2338758 0.79 EPHX1 (0.36) KIF11ARSCN8ASLC22A12AKR1C3
SCHEMBL7020637 0.79 KMO (0.38) KIF11ARSCN8ASLC22A12AKR1C3
SCHEMBL27821736 0.79 KMO (0.33) KIF11ARSCN8ASLC22A12AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3619209-A1 SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS Glenmark Pharmaceuticals S.A. (CH) 2020-03-11 EP disclosed
WO-2018203298-A1 SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2018-11-08 WO disclosed
EP-2358710-A1 AKT AND P70 S6 KINASE INHIBITORS Eli Lilly and Company (US) 2011-08-24 EP disclosed
EP-2265606-A1 HEPATITIS C VIRUS INHIBITORS Bristol-Myers Squibb Company (US) 2010-12-29 EP disclosed
WO-2010056563-A1 AKT AND P70 S6 KINASE INHIBITORS ELI LILLY AND COMPANY (US) 2010-05-20 WO disclosed
WO-2009129109-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-10-22 WO disclosed
EP-1874765-A2 UREA DERIVATIVES METHODS FOR THEIR MANUFACTURE AND USES THEREOF Proskelia SAS (FR) 2008-01-09 EP disclosed
WO-2006117211-A2 UREA DERIVATIVES METHODS FOR THEIR MANUFACTURE AND USES THEREOF PROSKELIA SAS (FR) 2006-11-09 WO disclosed