Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12213909 | 0.79 | POLB (0.46) | POLBTSHRKDM4ERAB9ACA12 | |
| SCHEMBL22168551 | 0.79 | POLB (0.35) | POLB | |
| SCHEMBL13588042 | 0.79 | EPHX1 (0.36) | POLBKDM4ERAB9ACYP2C9SMN1; SMN2 | |
| SCHEMBL5019737 | 0.72 | POLB (0.48) | POLBTSHRRAB9ACA12CA1 | |
| SCHEMBL11950246 | 0.70 | EPHX1 (0.34) | KDM4ERAB9ACYP2C9SMN1; SMN2EPHX1 | |
| SCHEMBL18743005 | 0.70 | RAB9A (0.36) | KDM4ERAB9AMMP1MMP2MMP9 | |
| SCHEMBL6859267 | 0.69 | KDM4E (0.46) | POLBKDM4ERAB9ACYP2C9SMN1; SMN2 | |
| SCHEMBL138082 | 0.69 | EPHX1 (0.41) | POLBKDM4ERAB9ACYP2C9SMN1; SMN2 | |
| SCHEMBL9171219 | 0.69 | ALDH1A1 (0.36) | POLBKDM4ERAB9ACYP2C9SMN1; SMN2 | |
| SCHEMBL3277816 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3359154-B1 | WNT SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF | Suzhou Yunxuan Yiyao Keji Youxian Gongsi (CN) | 2021-05-26 | — | — | EP | disclosed |