Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | LPO | P22079 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18054292 | 0.89 | NOTUM (0.46) | NOTUMLMNALPOCYP1A2L3MBTL1 | |
| SCHEMBL18054355 | 0.87 | NOTUM (0.61) | NOTUMNPSR1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL20224102 | 0.86 | NOTUM (0.43) | NOTUMLMNALPOCYP1A2L3MBTL1 | |
| SCHEMBL20977769 | 0.85 | NOTUM (0.43) | NOTUMNPSR1LMNALPOCYP1A2 | |
| SCHEMBL18054331 | 0.83 | NPSR1 (0.39) | NOTUMNPSR1LMNALPOCYP1A2 | |
| SCHEMBL20224081 | 0.78 | NOTUM (0.41) | NOTUMLMNAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL20977761 | 0.77 | NOTUM (0.40) | NOTUMNPSR1L3MBTL1ALDH1A1HPGD | |
| SCHEMBL20227228 | 0.77 | NOTUM (0.40) | NOTUMALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL18054133 | 0.76 | ELANE (0.34) | NOTUMNPSR1LMNALPOCYP1A2 | |
| SCHEMBL18681981 | 0.76 | P2RX7 (0.38) | LMNAL3MBTL1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3261637-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE INC (US) | 2021-05-26 | — | — | EP | disclosed |