SCHEMBL23398490

SCHEMBL23398490

CCc1c(O)nn(-c2ccc(C)cc2)c1C(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CDK8 P49336 2/20 0.41
MAPK14 Q16539 5/20 0.39
ALDH1A1 P00352 5/20 0.37
MAPK13 O15264 2/20 0.37
MAPK12 P53778 2/20 0.37
MAPK11 Q15759 2/20 0.37
CNR1 P21554 1/20 0.37
CNR2 P34972 1/20 0.37
DDR2 Q16832 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
RAB9A P51151 2/20 0.36
NPC1 O15118 1/20 0.36
TP53 P04637 1/20 0.35
PTK2 Q05397 2/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CCNC P24863 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23399379 0.88 USP2 (0.41) CDK8MAPK14ALDH1A1MAPK13MAPK12
SCHEMBL23400014 0.87 CDK8 (0.36) CDK8MAPK14ALDH1A1MAPK13MAPK12
SCHEMBL23398845 0.86 LMNA (0.40) MAPK14ALDH1A1MAPK13MAPK12MAPK11
SCHEMBL23403425 0.84 CDK8 (0.36) CDK8MAPK14ALDH1A1MAPK13MAPK12
SCHEMBL23402863 0.83 RIPK2 (0.43) MAPK14ALDH1A1MAPK13MAPK12MAPK11
SCHEMBL23399792 0.81 CDK8 (0.41) CDK8MAPK14ALDH1A1MAPK13MAPK12
SCHEMBL23400167 0.81 ALDH1A1 (0.43) CDK8ALDH1A1SMN1; SMN2RAB9ANPC1
SCHEMBL23402891 0.80 CDK8 (0.43) CDK8MAPK14ALDH1A1MAPK13MAPK12
SCHEMBL23399010 0.80 ALDH1A1 (0.37) CDK8MAPK14ALDH1A1SMN1; SMN2RAB9A
SCHEMBL23400313 0.79 CDK8 (0.41) CDK8MAPK14ALDH1A1MAPK13MAPK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3828159-A1 STORAGE AND TRANSPORT STABILIZERS FOR POLYMERIZABLE COMPOUNDS BASF SE (DE) 2021-06-02 EP disclosed