Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 2/20 | 0.33 |
| ▸ | PGK2 | P07205 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5930051 | 0.80 | PTPN1 (0.45) | PTPN1CA2CA4CA12CA1 | |
| SCHEMBL2171752 | 0.79 | CA2 (0.71) | CA2CA4CA5ALMNATSHR | |
| SCHEMBL28991589 | 0.77 | PTPN1 (0.44) | PTPN1CA2CA4CA12CA1 | |
| SCHEMBL14681173 | 0.76 | PTPN1 (0.42) | PTPN1CA2CA4CA12CA1 | |
| SCHEMBL4730266 | 0.76 | MMP2 (0.52) | CA2CA4CA5ACA12CA1 | |
| SCHEMBL238426 | 0.76 | CA2 (0.48) | PTPN1CA2CA4CA5ALMNA | |
| Phenylacetylene SCHEMBL31310787 | 0.73 | PTPN1 (0.53) | PTPN1CA2CA4CA5ACA12 | |
| SCHEMBL28871 | 0.72 | HDAC8 (0.59) | PTPN1CA2CA4CA12CA1 | |
| SCHEMBL13284241 | 0.71 | SRC (0.54) | PTPN1CA2CA4CA12CA1 | |
| SCHEMBL22999982 | 0.71 | CA2 (0.60) | CA2CA4CA5ACA14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1231227-B1 | POLY(PHOSPHONOARYLACETYLENE) AND CHIRAL SENSOR COMPRISING THE SAME | JAPAN SCIENCE & TECH AGENCY (JP) | 2007-06-20 | — | — | EP | claimed |
| US-6559258-B2 | Circular dichroism in the presence of an optically active substance | JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) | 2003-05-06 | — | — | US | claimed |
| US-20020156217-A1 | Poly (phosphonoarylacetylene and chiral sensor comprising the same | JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) | 2002-10-24 | — | — | US | claimed |
| EP-1231227-A1 | POLY(PHOSPHONOARYLACETYLENE) AND CHIRAL SENSOR COMPRISING THE SAME | Japan Science and Technology Corporation (JP) | 2002-08-14 | — | — | EP | claimed |
| US-11515154-B2 | Selective deposition of a passivation film | APPLIED MATERIALS, INC. (US) | 2022-11-29 | — | — | US | disclosed |
| WO-2022093804-A1 | SELECTIVE DEPOSITION OF A PASSIVATION FILM | APPLIED MATERIALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |
| US-20220130660-A1 | Selective Deposition Of A Passivation Film | APPLIED MATERIALS, INC. (US) | 2022-04-28 | — | — | US | disclosed |
| EP-1305015-B1 | SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2013-06-12 | — | — | EP | disclosed |
| EP-2359819-A1 | Substituted styryl benzylsulfones for treating proliferative disorders | Temple University - Of The Commonwealth System of Higher Education (US) | 2011-08-24 | — | — | EP | disclosed |
| EP-1231227-B1 | POLY(PHOSPHONOARYLACETYLENE) AND CHIRAL SENSOR COMPRISING THE SAME | JAPAN SCIENCE & TECH AGENCY (JP) | 2007-06-20 | — | — | EP | disclosed |
| EP-1379228-A4 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | UNIV TEMPLE (US) | 2006-01-04 | — | — | EP | disclosed |
| US-6833480-B2 | Useful in inhibiting proliferation of and/or killing cancer cells | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2004-12-21 | — | — | US | disclosed |
| US-20030036536-A1 | Useful as antiproliferative agents, including, for example, anticancer agents | REDDY E PREMKUMAR (US) | 2003-02-20 | — | — | US | disclosed |
| US-6486210-B2 | SUCH AS ENANTIOMORPHS OF 4-FLUOROSTYRYL-2,3,4,5,6-PENTAFLUOROBENZYLSULFONE; ANTIPROLIFERATIVE/ANTICANCER AGENTS | Temple University—Of the Commonwealth System of Higher Education | 2002-11-26 | — | — | US | disclosed |
| WO-2002067913-A8 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | UNIV TEMPLE (US) | 2002-11-14 | — | — | WO | disclosed |
| US-20020156217-A1 | Poly (phosphonoarylacetylene and chiral sensor comprising the same | JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) | 2002-10-24 | — | — | US | disclosed |
| WO-2002067913-A1 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2002-09-06 | — | — | WO | disclosed |
| US-20020115643-A1 | Substituted styryl benzylsulfones for treating proliferative disorders | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2002-08-22 | — | — | US | disclosed |
| EP-1231227-A1 | POLY(PHOSPHONOARYLACETYLENE) AND CHIRAL SENSOR COMPRISING THE SAME | Japan Science and Technology Corporation (JP) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001078712-A1 | SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036536-A1 | Useful as antiproliferative agents, including, for example, anticancer agents | MKI67, MCL1, CCNA1 | PTPN1 2943/4885CA2 3943/4885CA4 3458/4885 |
| US-20020115643-A1 | Substituted styryl benzylsulfones for treating proliferative disorders | HCCS, CCNO, HRAS | PTPN1 1021/4885CA2 1209/4885CA4 1394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.