Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068492 | 0.85 | RIPK1 (0.64) | RIPK1MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL2338748 | 0.83 | HDAC1 (0.50) | RIPK1SMN1; SMN2KDM4EATMMEN1 | |
| SCHEMBL2336064 | 0.82 | RIPK1 (0.46) | RIPK1MEN1KMT2ALMNACTSB | |
| SCHEMBL6432691 | 0.74 | HDAC1 (0.48) | RIPK1SMN1; SMN2CTSBCTSSCTSK | |
| SCHEMBL28978282 | 0.74 | RIPK1 (0.83) | RIPK1SMN1; SMN2KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6415341 | 0.72 | CCR5 (0.41) | SMN1; SMN2KDM4EATMMEN1KMT2A | |
| SCHEMBL5306993 | 0.72 | CCR5 (0.43) | RIPK1SMN1; SMN2KDM4EATMMEN1 | |
| SCHEMBL17608805 | 0.72 | HDAC1 (0.55) | RIPK1ATMMEN1KMT2ACTSB | |
| SCHEMBL28978314 | 0.72 | RIPK1 (0.72) | RIPK1MAPK1 | |
| Hydrochloric Acid SCHEMBL6409219 | 0.71 | CCR5 (0.43) | RIPK1SMN1; SMN2KDM4EATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786815-B1 | SPIRO COMPOUNDS AND METHODS FOR THE MODULATION OF CHEMOKINE RECEPTOR ACTIVITY | VIROCHEM PHARMA INC (CA) | 2011-08-24 | — | — | EP | disclosed |