Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 1.00 |
| ▸ | AKT1 | P31749 | 14/20 | 0.77 |
| ▸ | MTOR | P42345 | 8/20 | 0.70 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21469765 | 1.00 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL23426339 | 0.95 | PIK3CA (0.90) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL29922692 | 0.87 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL21469886 | 0.87 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL21465336 | 0.82 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL23438764 | 0.82 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL21465337 | 0.82 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL21469824 | 0.82 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL21469827 | 0.82 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL29923044 | 0.82 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265086-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2023-08-24 | — | — | US | disclosed |
| US-11492348-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | NEUROPORE THERAPIES, INC. (US) | 2022-11-08 | — | — | US | disclosed |
| US-20210163462-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492348-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | ATG7, ULK1, BECN1 | PIK3CA 31/4885AKT1 34/4885MTOR 4/4885 |
| US-20210163462-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | ATG7, ULK1, BECN1 | PIK3CA 31/4885AKT1 34/4885MTOR 4/4885 |
| US-20230265086-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | ATG7, ULK1, BECN1 | PIK3CA 31/4885AKT1 34/4885MTOR 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.