Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.32 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.32 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23447200 | 1.00 | MAPT (0.38) | MAPTMEN1KMT2AGAAIKBKB | |
| SCHEMBL25178039 | 0.79 | MEN1 (0.41) | MEN1KMT2AGAA | |
| SCHEMBL24536430 | 0.77 | MEN1 (0.44) | MEN1KMT2AGAABRD4 | |
| SCHEMBL17996703 | 0.77 | MTNR1A (0.53) | MAPTGAAIKBKBTP53MAPK1 | |
| SCHEMBL29903185 | 0.75 | BRD4 (0.35) | MEN1KMT2AGAABRD4MAP1LC3B | |
| SCHEMBL23409365 | 0.71 | ALDH1A1 (0.34) | MAPTMEN1KMT2AGAABRD4 | |
| SCHEMBL29903175 | 0.71 | ALDH1A1 (0.34) | MAPTMEN1KMT2AGAABRD4 | |
| SCHEMBL3241051 | 0.70 | TP53 (0.64) | MAPTGAAIKBKBTP53RECQL | |
| SCHEMBL28608577 | 0.70 | HTR2C (0.47) | MAPTIKBKBMAP1LC3BTP53RECQL | |
| SCHEMBL21733468 | 0.70 | HTR1A (0.44) | MAPTIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4065583-A1 | A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION | Taiho Pharmaceutical Co., Ltd. (JP) | 2022-10-05 | — | — | EP | disclosed |
| WO-2021106231-A1 | A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-06-03 | — | — | WO | disclosed |
| WO-2021107160-A1 | A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-06-03 | — | — | WO | disclosed |