Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10165179 | 0.83 | NAMPT (0.56) | GAAMAPTCA1CA2HDAC6 | |
| SCHEMBL19682558 | 0.83 | KMT2A (0.60) | GAAALDH1A1MAPTCA1CA2 | |
| SCHEMBL6945571 | 0.83 | HTT (0.50) | HTTGAAMAPTCA1CA2 | |
| SCHEMBL13884422 | 0.83 | CA1 (0.49) | HTTGAAALDH1A1HPGDCA1 | |
| SCHEMBL18954397 | 0.79 | EPHX2 (0.50) | GAACA1CA2HDAC6EPHX2 | |
| SCHEMBL22837952 | 0.79 | EPHX2 (0.47) | GAACA1CA2HDAC6EPHX2 | |
| SCHEMBL508555 | 0.79 | CA1 (0.49) | ALDH1A1CA1CA2HDAC6MEN1 | |
| SCHEMBL8562874 | 0.79 | SMO (0.46) | GAACA1CA2HDAC6EPHX2 | |
| SCHEMBL1949206 | 0.79 | CA1 (0.51) | HTTCA1CA2HDAC6EPHX2 | |
| SCHEMBL34481 | 0.78 | CA1 (0.53) | GAAHPGDMAPTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-114787145-A | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 奥里戈生物制药有限公司 | 2022-07-22 | — | — | CN | disclosed |
| WO-2021105317-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | ORIGO BIOPHARMA, S.L. (ES) | 2021-06-03 | — | — | WO | disclosed |