Sugi Predict

Sugi Predict / Compounds / SCHEMBL2340986

SCHEMBL2340986

SCHEMBL2340986

Cn1nnnc1NC(=O)N1CCC2(CC1)CC(c1cccc(Oc3ccc(C(F)(F)F)cn3)c1)C2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SCN9A Q15858 11/20 0.48
▸ CYP3A4 P08684 4/20 0.46
▸ CYP2D6 P10635 4/20 0.46
▸ FAAH O00519 3/20 0.46
▸ GABRA1 P14867 1/20 0.46
▸ ADRA2C P18825 1/20 0.46
▸ CNR1 P21554 1/20 0.46
▸ HTR2A P28223 1/20 0.46
▸ HTR2C P28335 1/20 0.46
▸ CNR2 P34972 1/20 0.46
▸ HTR2B P41595 1/20 0.46
▸ TMEM97 Q5BJF2 1/20 0.46
▸ SIGMAR1 Q99720 1/20 0.46
▸ KDM4E B2RXH2 1/20 0.42
▸ LMNA P02545 1/20 0.42
▸ MAPK1 P28482 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ MGLL Q99685 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2341589 0.85 MGLL (0.49) CYP3A4LMNAHTTMGLL
SCHEMBL2344291 0.84 MGLL (0.51) MGLL
SCHEMBL2341789 0.84 FAAH (0.66) SCN9ACYP3A4CYP2D6FAAHGABRA1
SCHEMBL3238559 0.82 SCN9A (0.55) SCN9ACYP3A4FAAHHTTSMN1; SMN2
SCHEMBL2336329 0.82 CYP3A4 (0.47) SCN9ACYP3A4CYP2D6FAAHGABRA1
SCHEMBL2340103 0.81 SCN9A (0.51) SCN9AFAAHMAPK1MGLL
SCHEMBL2340962 0.80 FAAH (0.49) SCN9ACYP3A4CYP2D6FAAHGABRA1
SCHEMBL12295664 0.78 FAAH (0.41) CYP3A4CYP2D6FAAHGABRA1ADRA2C
SCHEMBL2423606 0.78 FAAH (0.41) CYP3A4CYP2D6FAAHGABRA1ADRA2C
SCHEMBL2341745 0.78 MGLL (0.47) CYP3A4CYP2D6GABRA1MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2358704-A1 7-azaspiro [3.5]nonane-7-carboxamide compounds as modulators of fatty acid amide hydrolase Pfizer Inc. (US) 2011-08-24 — — EP claimed
US-20100113465-A1 7-AZASPIRO[3.5]NONANE-7-CARBOXAMIDE COMPOUNDS PFIZER INC. 2010-05-06 — — US claimed
WO-2010049841-A1 7-AZASPIRO [3.5] NONANE-7-CARBOXAMIDE COMPOUNDS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE PFIZER INC. (US) 2010-05-06 — — WO claimed
US-20100113465-A1 7-AZASPIRO[3.5]NONANE-7-CARBOXAMIDE COMPOUNDS PFIZER INC. 2010-05-06 — — US disclosed
US-20100113465-A1 7-AZASPIRO[3.5]NONANE-7-CARBOXAMIDE COMPOUNDS PFIZER INC. 2010-05-06 — — US disclosed
US-20100113465-A1 7-AZASPIRO[3.5]NONANE-7-CARBOXAMIDE COMPOUNDS PFIZER INC. 2010-05-06 — — US disclosed
WO-2010049841-A1 7-AZASPIRO [3.5] NONANE-7-CARBOXAMIDE COMPOUNDS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE PFIZER INC. (US) 2010-05-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100113465-A1 7-AZASPIRO[3.5]NONANE-7-CARBOXAMIDE COMPOUNDS FAAH, FAAH2, APEH SCN9A 1999/4885CYP3A4 912/4885CYP2D6 875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.