Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | DHODH | Q02127 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689929 | 0.87 | LMNA (0.69) | HTTMAPTDHODHNFKB1MAPK1 | |
| SCHEMBL12478898 | 0.86 | DHODH (0.65) | HTTMAPTDHODHNPC1RAB9A | |
| SCHEMBL11833609 | 0.85 | HTT (0.68) | HTTMAPTDHODHNPC1RAB9A | |
| SCHEMBL12478838 | 0.84 | RAB9A (0.65) | HTTMAPTDHODHNPC1RAB9A | |
| SCHEMBL10377167 | 0.83 | RAB9A (0.70) | HTTMAPTDHODHNPC1RAB9A | |
| SCHEMBL17363214 | 0.82 | MAPT (0.51) | MAPTDHODHNPC1RAB9ANFKB1 | |
| SCHEMBL17181734 | 0.82 | HTT (0.53) | HTTMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL23388857 | 0.81 | DHODH (0.74) | HTTMAPTDHODHNPC1RAB9A | |
| SCHEMBL22452610 | 0.81 | DHODH (0.51) | HTTMAPTDHODHNPC1RAB9A | |
| SCHEMBL23388895 | 0.80 | LMNA (0.58) | MAPTDHODHNPC1RAB9ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021102204-A1 | HETEROARYL COMPOUNDS | VIVACE THERAPEUTICS, INC. (US) | 2021-05-27 | — | — | WO | disclosed |