SCHEMBL234294

SCHEMBL234294

CCNC(NCC)N([SiH3])c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.41
ALDH1A1 P00352 4/20 0.37
TSHR P16473 2/20 0.34
GLA P06280 1/20 0.34
KDM4E B2RXH2 2/20 0.33
MAPT P10636 2/20 0.33
ALOX12 P18054 1/20 0.33
HTT P42858 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
KCNN4 O15554 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.31
POLB P06746 1/20 0.31
APOBEC3A P31941 1/20 0.31
APOBEC3G Q9HC16 1/20 0.31
NR3C2 P08235 1/20 0.31
TP53 P04637 1/20 0.31
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL236026 0.77 TSHR (0.39) SIGMAR1TSHRGLAALOX12HTT
SCHEMBL17053464 0.71 TSHR (0.41) SIGMAR1ALDH1A1TSHRGLAPOLB
SCHEMBL6114331 0.69 ALDH1A1 (0.39) ALDH1A1HTTMEN1KMT2APOLB
SCHEMBL6114555 0.66 TSHR (0.48) ALDH1A1TSHRGLAKDM4EMAPT
SCHEMBL27850764 0.64 SIGMAR1 (0.45) SIGMAR1ALDH1A1TSHRMAPTALOX12
SCHEMBL16198577 0.63 ALDH1A1 (0.42) SIGMAR1ALDH1A1TSHRGLAKDM4E
SCHEMBL1485821 0.63 SIGMAR1 (0.48) SIGMAR1ALDH1A1TSHRMAPTALOX12
SCHEMBL6666470 0.63 ALDH1A1 (0.47) ALDH1A1TSHRGLAKDM4EMAPT
SCHEMBL14139798 0.63 SIGMAR1 (0.48) SIGMAR1ALDH1A1TSHRMAPTALOX12
SCHEMBL29028762 0.63 ALDH1A1 (0.52) ALDH1A1TSHRGLAKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2360190-B1 SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS USING SAME TOHO TITANIUM CO LTD (JP) 2015-10-14 EP disclosed
US-8426537-B2 Solid catalyst component and catalyst for polymerization of olefins, and process for production of olefin polymers using same TOHO TITANIUM CO., LTD. (JP) 2013-04-23 US disclosed
US-20120004378-A1 SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS USING SAME TOHO TITANIUM CO., LTD (JP) 2012-01-05 US disclosed
EP-2360190-A1 SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS USING SAME Toho Titanium CO., LTD. (JP) 2011-08-24 EP disclosed