Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.64 |
| ▸ | CLK2 | P49760 | 2/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.64 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | PRKX | P51817 | 2/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23430082 | 0.87 | NPC1 (0.65) | ROCK2ROCK1NPC1RAB9AMAP4K4 | |
| SCHEMBL23429984 | 0.87 | ROCK2 (0.64) | ROCK2ROCK1NPC1RAB9AMAP4K4 | |
| SCHEMBL29099846 | 0.87 | ROCK1 (0.64) | ROCK2ROCK1NPC1RAB9AMAP4K4 | |
| SCHEMBL1457361 | 0.87 | ROCK2 (0.63) | ROCK2ROCK1NPC1RAB9AMAP4K4 | |
| SCHEMBL20661217 | 0.85 | ROCK2 (0.65) | ROCK2ROCK1NPC1RAB9AMAP4K4 | |
| SCHEMBL20661265 | 0.82 | ROCK2 (0.67) | ROCK2ROCK1NPC1RAB9AMAP4K4 | |
| SCHEMBL23430027 | 0.81 | ROCK2 (0.56) | ROCK2ROCK1NPC1RAB9AMAP4K4 | |
| SCHEMBL20672744 | 0.81 | ROCK2 (0.65) | ROCK2ROCK1NPC1RAB9AMAP4K4 | |
| SCHEMBL23430169 | 0.81 | ROCK2 (0.59) | ROCK2ROCK1NPC1RAB9AMAP4K4 | |
| SCHEMBL15764676 | 0.78 | NPC1 (1.00) | ROCK2ROCK1NPC1RAB9AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163421-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON PHARMACEUTICALS, LLC | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163421-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885NPC1 2291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.