Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23430082 | 0.88 | NPC1 (0.65) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL20672744 | 0.88 | ROCK2 (0.65) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL23430169 | 0.88 | ROCK2 (0.59) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL23429983 | 0.87 | ROCK2 (0.64) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL1457361 | 0.87 | ROCK2 (0.63) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL2555843 | 0.85 | ROCK2 (0.64) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL2555842 | 0.85 | ROCK2 (0.64) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL20672732 | 0.85 | MEN1 (0.62) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL23430076 | 0.85 | NPC1 (0.67) | ROCK2ROCK1NPC1RAB9AALDH1A1 | |
| SCHEMBL23430027 | 0.83 | ROCK2 (0.56) | ROCK2ROCK1NPC1RAB9AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163421-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON PHARMACEUTICALS, LLC | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163421-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885NPC1 2291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.