Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2344717 | 0.89 | SYK (0.37) | SYKKCNH2MAP4K1PRKCIMAPK1 | |
| SCHEMBL2342577 | 0.87 | ALDH1A1 (0.40) | SYKKCNH2MAPK1CYP2D6CYP2C9 | |
| SCHEMBL2362648 | 0.87 | JAK3 (0.36) | SYKKCNH2MAP4K1MAPK1CYP2D6 | |
| SCHEMBL2273872 | 0.84 | SYK (0.58) | SYKKCNH2CYP2D6 | |
| SCHEMBL2348276 | 0.81 | SYK (0.38) | SYKKCNH2MAP4K1PRKCICYP2D6 | |
| SCHEMBL2278709 | 0.80 | JAK3 (0.55) | SYKKCNH2PRKCIKITMAPK1 | |
| SCHEMBL2281125 | 0.79 | JAK3 (0.54) | SYKKCNH2PRKCIKITMAPK1 | |
| SCHEMBL2341691 | 0.78 | SYK (0.43) | SYKMAP4K1PRKCIJAK3CYP2C9 | |
| SCHEMBL2278520 | 0.78 | JAK3 (0.55) | SYKKCNH2PRKCIMAPK1CYP2D6 | |
| SCHEMBL2348404 | 0.78 | SYK (0.55) | SYKMAP4K1KITDYRK1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |