Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | IDH1 | O75874 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2275136 | 0.87 | JAK3 (0.49) | JAK3SYKKCNH2CYP2D6 | |
| SCHEMBL2349020 | 0.87 | SYK (0.41) | JAK3MAP4K1SYKKCNH2CYP2D6 | |
| SCHEMBL2349156 | 0.86 | JAK3 (0.39) | JAK3MAP4K1SYKADORA2A | |
| SCHEMBL1892513 | 0.84 | JAK3 (0.51) | JAK3SYKIDH1ADORA2A | |
| SCHEMBL2344717 | 0.83 | SYK (0.37) | JAK3MAP4K1SYKKCNH2CYP2D6 | |
| SCHEMBL3061667 | 0.82 | PRKAB2 (0.43) | JAK3MAP4K1SYKIDH1ADORA2A | |
| SCHEMBL12372234 | 0.80 | MAP4K1 (0.39) | JAK3MAP4K1SYKIDH1ADORA2A | |
| SCHEMBL2342577 | 0.80 | ALDH1A1 (0.40) | SYKKCNH2CYP2D6MAPK1 | |
| SCHEMBL3396539 | 0.78 | JAK3 (0.36) | JAK3MAP4K1IDH1ADORA2ACDC7 | |
| SCHEMBL2274966 | 0.76 | JAK3 (0.52) | JAK3SYKCYP2D6ATRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |