Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1928525 | 0.83 | HDAC3 (0.45) | BACE1AGTR1AGTR2HDAC3HDAC1 | |
| SCHEMBL3615871 | 0.73 | HDAC3 (0.42) | BACE1AGTR1AGTR2HDAC3HDAC1 | |
| SCHEMBL1929153 | 0.71 | HTR2C (0.42) | HCRTR1PAX8 | |
| SCHEMBL2347049 | 0.68 | NPSR1 (0.37) | ALDH1A1MAPTNPSR1POLBPAX8 | |
| SCHEMBL19812532 | 0.68 | P2RY12 (0.40) | MAPTPOLB | |
| SCHEMBL18730955 | 0.65 | SSTR4 (0.34) | ALDH1A1PAX8 | |
| SCHEMBL18902072 | 0.65 | PAX8 (0.30) | PAX8 | |
| SCHEMBL18731533 | 0.64 | SSTR4 (0.39) | AGTR1AGTR2HDAC3HDAC1HDAC2 | |
| SCHEMBL1925923 | 0.64 | CTSK (0.48) | ALDH1A1MAPTCTSLCTSBCTSS | |
| SCHEMBL6812673 | 0.64 | CACNA1G (0.42) | ALDH1A1MAPTPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228760-B1 | 5-membered heterocycle derivatives, production thereof and use thereof as medicaments | IPSEN PHARMA (FR) | 2011-08-31 | — | — | EP | claimed |