Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23451957 | 0.89 | GABRG2 (0.46) | LMNAIKBKBNPC1RAB9AKDM4E | |
| SCHEMBL23451958 | 0.83 | KDM4E (0.41) | IKBKBNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL21723989 | 0.82 | NPC1 (0.48) | IKBKBNPC1RAB9AKDM4EPKM | |
| SCHEMBL21723987 | 0.82 | NPC1 (0.48) | IKBKBNPC1RAB9AKDM4EPKM | |
| SCHEMBL23451952 | 0.81 | FEN1 (0.48) | KDM4EALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL23452111 | 0.79 | IKBKB (0.47) | LMNAIKBKBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL23452113 | 0.78 | ALDH1A1 (0.44) | LMNAIKBKBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL21723639 | 0.78 | HSD17B10 (0.47) | NPC1RAB9AKDM4EPKMALDH1A1 | |
| SCHEMBL23452066 | 0.77 | ALDH1A1 (0.53) | LMNARAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL23452100 | 0.75 | GABRG2 (0.47) | IKBKBNPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11306103-B2 | Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof | KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY | 2022-04-19 | — | — | US | disclosed |
| US-11306103-B2 | Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof | KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY | 2022-04-19 | — | — | US | disclosed |
| US-20210171539-A1 | NOVEL THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KR) | 2021-06-10 | — | — | US | disclosed |
| US-20210171539-A1 | NOVEL THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KR) | 2021-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210171539-A1 | NOVEL THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | BRD4, BRPF3, AFF4 | LMNA 4745/4885IKBKB 3276/4885NPC1 4239/4885 |
| US-11306103-B2 | Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof | BRD4, BRPF3, AFF4 | LMNA 4738/4885IKBKB 3066/4885NPC1 4212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.