⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1533911 | 0.73 | — | — | |
| SCHEMBL3890237 | 0.72 | PGK1 (0.36) | — | |
| SCHEMBL2459230 | 0.69 | LMNA (0.33) | — | |
| SCHEMBL777454 | 0.67 | PGK1 (0.32) | — | |
| SCHEMBL2814420 | 0.67 | LMNA (0.38) | — | |
| SCHEMBL641074 | 0.66 | — | — | |
| SCHEMBL2000403 | 0.65 | FDPS (0.30) | — | |
| SCHEMBL777401 | 0.65 | PGK1 (0.40) | — | |
| SCHEMBL28491843 | 0.65 | — | — | |
| Phosphoric Acid SCHEMBL28521742 | 0.65 | PGK1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2481743-B1 | LPA receptor agonists and antagonists and methods of use | UNIV TENNESSEE RES FOUND (US) | 2017-03-22 | — | — | EP | disclosed |
| EP-2433946-B1 | LPA receptor agonists and antagonists and methods of use | UNIV TENNESSEE RES FOUNDATION (US) | 2016-04-20 | — | — | EP | disclosed |
| EP-2481743-A1 | LPA receptor agonists and antagonists and methods of use | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20120135967-A1 | LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE | MILLER DUANE D (US) | 2012-05-31 | — | — | US | disclosed |
| EP-2433946-A1 | LPA receptor agonists and antagonists and methods of use | University of Tennessee Research Foundation (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1678096-B1 | LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE | UNIV TENNESSEE RES FOUNDATION (US) | 2012-01-04 | — | — | EP | disclosed |
| US-7947665-B2 | lysophosphatidic acid receptor modulator; thiophosphoric acid O-[7-(4-octyl-phenyl)-heptyl] ester; treating cancer, wounds, skin disorders and apoptosis; preserving or restoring function in a cell, tissue or organ; culturing cells; preserving organ or tissue function; and enhancing cell proliferation | MILLER DUANE D | 2011-05-24 | — | — | US | disclosed |
| US-20080090783-A1 | lysophosphatidic acid receptor modulator; thiophosphoric acid O-[7-(4-octyl-phenyl)-heptyl] ester; treating cancer, wounds, skin disorders and apoptosis; preserving or restoring function in a cell, tissue or organ; culturing cells; preserving organ or tissue function; and enhancing cell proliferation | MILLER DUANE D | 2008-04-17 | — | — | US | disclosed |
| US-7217704-B2 | LPA receptor agonists and antagonists and methods of use | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2007-05-15 | — | — | US | disclosed |
| EP-1678096-A4 | LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE | UNIV TENNESSEE RES CORP (US) | 2007-04-18 | — | — | EP | disclosed |
| EP-1678096-A2 | LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE | THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) | 2006-07-12 | — | — | EP | disclosed |
| US-20060009507-A1 | Thio-phosphoric and -phosphorous acid derivatives; treating cancer, wounds, skin disorders and apoptosis; preserving or restoring function in a cell, tissue or organ; culturing cells; preserving organ or tissue function; and enhancing cell proliferation | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2006-01-12 | — | — | US | disclosed |
| WO-2005032494-A2 | LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2005-04-14 | — | — | WO | disclosed |
| EP-1502950-A2 | Method for purifying chemically modified RNA | RIBOZYME PHARMACEUTICALS, INC. (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1260586-A2 | Method and reagent for inhibiting the expression of disease related genes | RIBOZYME PHARMACEUTICALS, INC. (US) | 2002-11-27 | — | — | EP | disclosed |
| JP-2002080485-A | NEW NORBORNENE ANALOGOUS COMPOUND | HISAMITSU PHARMACEUT CO INC | 2002-03-19 | — | — | JP | disclosed |
| EP-0746614-A1 | METHOD AND REAGENT FOR INHIBITING THE EXPRESSION OF DISEASE RELATED GENES | RIBOZYME PHARMACEUTICALS, INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995023225-A2 | METHOD AND REAGENT FOR INHIBITING THE EXPRESSION OF DISEASE RELATED GENES | RIBOZYME PHARMACEUTICALS, INC. (US) | 1995-08-31 | — | — | WO | disclosed |