Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337412 | 0.84 | NPC1 (0.57) | ALDH1A1NPC1RAB9AHSP90AA1MEN1 | |
| SCHEMBL27516651 | 0.82 | NPC1 (0.55) | ALDH1A1NPC1RAB9AHSP90AA1MEN1 | |
| SCHEMBL27307708 | 0.82 | NPC1 (0.55) | ALDH1A1NPC1RAB9AHSP90AA1MEN1 | |
| SCHEMBL6288070 | 0.82 | CA12 (0.46) | ALDH1A1NPC1RAB9AHSP90AA1MEN1 | |
| SCHEMBL4746034 | 0.82 | RAB9A (0.62) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28753388 | 0.80 | CA1 (0.73) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28993944 | 0.80 | CA1 (0.80) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL14470122 | 0.80 | KDM4E (0.50) | ALDH1A1MEN1KMT2ACA1CA2 | |
| SCHEMBL23600 | 0.80 | CA1 (0.80) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL24339221 | 0.79 | RAB9A (0.53) | ALDH1A1NPC1RAB9AHSP90AA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250011330-A1 | Imidazo[1,2- a]pyrazine and Imidazo[1,2- a]pyridine Based Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors | LEIDOS BIOMEDICAL RESEARCH INC. | 2025-01-09 | — | — | US | disclosed |
| EP-4284798-A1 | IMIDAZO[1,2-A]PYRAZINE AND IMIDAZO[1,2-A]PYRIDINE BASED TYROSYL-DNA PHOSPHODIESTERASE I (TDP1) INHIBITORS | The USA, as represented by The Secretary, Department of Health and Human Services (US) | 2023-12-06 | — | — | EP | disclosed |
| WO-2022164934-A1 | IMIDAZO[1,2-A]PYRAZINE AND IMIDAZO[1,2-A]PYRIDINE BASED TYROSYL-DNA PHOSPHODIESTERASE I (TDP1) INHIBITORS | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2022-08-04 | — | — | WO | disclosed |
| EP-2978751-B1 | TETRAHYDROISOQUINOLINES CONTAINING SUBSTITUTED AZOLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-12-05 | — | — | EP | disclosed |
| US-9862675-B1 | Method of N-formylating amines with a phosphonic anhydride | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2018-01-09 | — | — | US | disclosed |
| US-9738655-B2 | Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160145263-A1 | TETRAHYDROISOQUINOLINES CONTAINING SUBSTITUTED AZOLES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2016-05-26 | — | — | US | disclosed |
| EP-2978751-A1 | TETRAHYDROISOQUINOLINES CONTAINING SUBSTITUTED AZOLES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-02-03 | — | — | EP | disclosed |
| WO-2014160668-A1 | TETRAHYDROISOQUINOLINES CONTAINING SUBSTITUTED AZOLES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-10-02 | — | — | WO | disclosed |
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| US-5344933-A | Pyrrole ring-or condensed pyrrole ring-containing azomethine dye | FUJI PHOTO FILM CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| US-5262377-A | Colorfastness | FUJI PHOTO FILM CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| US-5238903-A | Azo-methine dye on support | FUJI PHOTO FILM CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| US-5227359-A | Pyrazoloazole dyes | FUJI PHOTO FILM CO., LTD. (JP) | 1993-07-13 | — | — | US | disclosed |
| EP-0540854-A2 | Preparation for promoting hair growth | Sansho Seiyaku Co., Ltd. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-5210200-A | Fast to heat and light | FUJI PHOTO FILM CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0518238-A1 | Pyrrolotriazole derivative | FUJI PHOTO FILM CO., LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-5128312-A | Thermal transfer dye donating material | FUJI PHOTO FILM CO., LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| EP-0423796-A1 | Thermal transfer dye donating materials | FUJI PHOTO FILM CO., LTD. (JP) | 1991-04-24 | — | — | EP | disclosed |
| US-4975409-A | Ketone imine dyes; colorfastness; copies | FUJI PHOTO FILM CO., LTD. (JP) | 1990-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250011330-A1 | Imidazo[1,2- a]pyrazine and Imidazo[1,2- a]pyridine Based Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors | TDP1, TDP2, TOP1 | ALDH1A1 769/4885NPC1 3699/4885RAB9A 4179/4885 |
| US-20160145263-A1 | TETRAHYDROISOQUINOLINES CONTAINING SUBSTITUTED AZOLES AS FACTOR XIA INHIBITORS | TFPI2, TFPI, F12 | ALDH1A1 3928/4885NPC1 3095/4885RAB9A 3375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.