SCHEMBL23458463

SCHEMBL23458463

c1cc(-c2nc3nccnc3s2)ccn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.50
PIK3CA P42336 1/20 0.50
PIK3CB P42338 1/20 0.50
PIK3CG P48736 1/20 0.50
KDM4E B2RXH2 3/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
MAPT P10636 2/20 0.44
CYP19A1 P11511 1/20 0.44
CDC7 O00311 8/20 0.41
DBF4 Q9UBU7 8/20 0.41
CCNE1 P24864 1/20 0.41
CDK2 P24941 1/20 0.41
ALDH1A1 P00352 2/20 0.40
HPGD P15428 2/20 0.40
HSD17B10 Q99714 2/20 0.40
IDO1 P14902 3/20 0.38
TDO2 P48775 3/20 0.38
POLB P06746 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24796218 0.85 ADORA3 (0.47) CDC7DBF4ALDH1A1
SCHEMBL21496515 0.79 PIK3CD (0.55) PIK3CDPIK3CAPIK3CBPIK3CGKDM4E
SCHEMBL29414542 0.75 KDM4E (0.50) PIK3CDPIK3CAPIK3CBPIK3CGKDM4E
SCHEMBL24796207 0.74 ENPP3 (0.33) KDM4ENPC1RAB9AMAPTCDK2
SCHEMBL23458481 0.74 KDM4E (0.59) PIK3CDPIK3CAPIK3CBPIK3CGKDM4E
SCHEMBL23458472 0.74 KDM4E (0.59) PIK3CDPIK3CAPIK3CBPIK3CGKDM4E
SCHEMBL13998697 0.73 KDM4E (0.53) KDM4ENPC1RAB9AMAPTALDH1A1
SCHEMBL13998686 0.73 NPC1 (0.50) KDM4ENPC1RAB9AMAPTALDH1A1
SCHEMBL23197226 0.72 PIK3CD (0.49) PIK3CDPIK3CAPIK3CBPIK3CGKDM4E
SCHEMBL23172585 0.71 KDM4E (0.41) KDM4ENPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021110890-A1 PYRIDINIUM DERIVATIVES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2021-06-10 WO disclosed
WO-2021110890-A1 PYRIDINIUM DERIVATIVES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2021-06-10 WO disclosed