Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KLK1 | P06870 | 1/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.54 |
| ▸ | STS | P08842 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339212 | 0.86 | NPC1 (0.59) | MAPTKDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL1696776 | 0.85 | MAPT (0.76) | MAPTKDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL1355519 | 0.83 | ALDH1A1 (0.55) | MAPTKDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL480276 | 0.83 | KDM4E (0.59) | MAPTKDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL9628988 | 0.82 | MAPT (0.54) | MAPTKDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL22588880 | 0.81 | KDM4E (0.57) | MAPTKDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL2066210 | 0.81 | KDM4E (0.57) | MAPTKDM4EHSD17B10ALDH1A1MAPK1 | |
| Acetic Acid SCHEMBL20596711 | 0.79 | KLKB1 (0.51) | MAPTKDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL23463729 | 0.79 | CYP3A4 (0.56) | MAPTKDM4EHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL8746603 | 0.78 | ALOX15 (0.56) | MAPTKDM4EHSD17B10ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163444-A1 | KINASE INHIBITORS FOR THE TREATMENT OF CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISORDERS | UNIVERSITY OF MIAMI | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163444-A1 | KINASE INHIBITORS FOR THE TREATMENT OF CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISORDERS | PNCK, PYGB, PMP22 | MAPT 360/4885KDM4E 3853/4885HSD17B10 3287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.