Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25147369 | 1.00 | DRD2 (0.43) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL23114442 | 0.84 | MAP4K4 (0.50) | DRD2DRD3HTR1APARP1DRD4 | |
| SCHEMBL12090447 | 0.84 | MAP4K4 (0.50) | DRD2DRD3HTR1APARP1DRD4 | |
| SCHEMBL23089594 | 0.79 | DRD2 (0.45) | DRD2DRD3HTR1APARP1PRMT5 | |
| SCHEMBL29814708 | 0.79 | DRD2 (0.45) | DRD2DRD3HTR1APARP1PRMT5 | |
| SCHEMBL23103376 | 0.77 | DRD2 (0.43) | DRD2DRD3PARP1PRMT5KCNH2 | |
| SCHEMBL23114439 | 0.77 | KCNH2 (0.46) | DRD2DRD3PARP1PRMT5KCNH2 | |
| SCHEMBL17896783 | 0.77 | MAP4K4 (0.53) | DRD2DRD3HTR1APARP1PRMT5 | |
| SCHEMBL23114418 | 0.77 | KCNH2 (0.46) | DRD2DRD3PARP1PRMT5KCNH2 | |
| SCHEMBL23103374 | 0.77 | DRD2 (0.43) | DRD2DRD3PARP1PRMT5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11028085-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists | Nimbus Saturn, Inc. (US) | 2021-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11028085-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists | HIPK1, PDXK, IP6K1 | DRD2 3269/4885DRD3 2710/4885HTR1A 450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.