Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 6/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12692509 | 0.87 | NUDT1 (0.53) | NUDT1CRHR1KCNH2TLR8TLR7 | |
| SCHEMBL9885084 | 0.79 | NUDT1 (0.51) | NUDT1TLR8TLR7JAK1L3MBTL1 | |
| SCHEMBL250475 | 0.79 | NUDT1 (0.51) | NUDT1TLR8TLR7JAK1L3MBTL1 | |
| SCHEMBL218367 | 0.79 | NUDT1 (0.51) | NUDT1TLR8TLR7JAK1L3MBTL1 | |
| SCHEMBL218369 | 0.75 | ADORA2A (0.41) | NUDT1CRHR1TLR8TLR7L3MBTL1 | |
| SCHEMBL9884961 | 0.72 | NUDT1 (0.55) | NUDT1TLR8L3MBTL1PIK3CDPIK3CB | |
| SCHEMBL9885018 | 0.72 | NUDT1 (0.55) | NUDT1TLR8L3MBTL1PIK3CDPIK3CB | |
| SCHEMBL20386651 | 0.72 | KCNH2 (0.59) | NUDT1KCNH2TLR8TLR7 | |
| SCHEMBL23472430 | 0.71 | TLR8 (0.57) | NUDT1KCNH2TLR8TLR7 | |
| SCHEMBL217587 | 0.70 | BCL6 (0.47) | NUDT1CRHR1KCNH2TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |