Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472281 | 0.93 | TLR7 (0.38) | TLR7TLR8 | |
| SCHEMBL15470083 | 0.88 | TLR8 (0.47) | TLR7TLR8ALDH1A1 | |
| SCHEMBL20219259 | 0.88 | ALDH1A1 (0.38) | TLR7TLR8ALDH1A1POLBPDE5A | |
| SCHEMBL20219600 | 0.88 | CNR1 (0.39) | TLR7TLR8ALDH1A1POLB | |
| SCHEMBL20219601 | 0.85 | TLR7 (0.37) | TLR7TLR8ALDH1A1POLB | |
| SCHEMBL23472630 | 0.83 | MAPT (0.39) | TLR7TLR8ALDH1A1 | |
| SCHEMBL23472466 | 0.83 | CYP1A2 (0.45) | TLR7TLR8ALDH1A1POLBPDE5A | |
| SCHEMBL20219401 | 0.83 | ALDH1A1 (0.43) | TLR7TLR8ALDH1A1POLBHTR2A | |
| SCHEMBL23472249 | 0.83 | PDE5A (0.40) | TLR7TLR8ALDH1A1PDE5AHTR2A | |
| SCHEMBL23472163 | 0.83 | TLR7 (0.49) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |