Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 6/20 | 0.35 |
| ▸ | CNR2 | P34972 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219600 | 0.95 | CNR1 (0.39) | TLR7TLR8PTGS2CNR1CNR2 | |
| SCHEMBL23472217 | 0.88 | TLR7 (0.45) | TLR7TLR8 | |
| SCHEMBL23472512 | 0.85 | TLR7 (0.38) | TLR7TLR8ALDH1A1POLB | |
| SCHEMBL20219723 | 0.84 | ALDH1A1 (0.38) | TLR7TLR8CNR1CNR2ALDH1A1 | |
| SCHEMBL15470058 | 0.83 | TLR7 (0.47) | TLR7TLR8 | |
| SCHEMBL23472281 | 0.82 | TLR7 (0.38) | TLR7TLR8 | |
| SCHEMBL23472163 | 0.81 | TLR7 (0.49) | TLR7TLR8 | |
| SCHEMBL13195680 | 0.81 | FLT3 (0.41) | TLR7TLR8CNR1CNR2ALDH1A1 | |
| SCHEMBL23472210 | 0.81 | MTNR1B (0.47) | TLR7TLR8MTNR1AMTNR1B | |
| SCHEMBL20219327 | 0.79 | MAPK1 (0.44) | TLR7TLR8ALDH1A1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |