Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.63 |
| ▸ | CPA1 | P15085 | 7/20 | 0.60 |
| ▸ | CPA3 | P15088 | 3/20 | 0.60 |
| ▸ | CPB1 | P15086 | 1/20 | 0.60 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MME | P08473 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664996 | 1.00 | KMO (0.63) | KMOCPA1CPA3CPB1CPB2 | |
| SCHEMBL2338269 | 1.00 | KMO (0.63) | KMOCPA1CPA3CPB1CPB2 | |
| SCHEMBL11244593 | 0.94 | TSHR (0.64) | KMOCPA1CPA3CPB1CPB2 | |
| SCHEMBL6675156 | 0.89 | NPC1 (0.53) | KMOCPA1CPA3CPB1CPB2 | |
| SCHEMBL7315538 | 0.89 | TSHR (0.75) | KMOCPA1CPA3CPB1CPB2 | |
| SCHEMBL3104186 | 0.89 | TSHR (0.75) | KMOCPA1CPA3CPB1CPB2 | |
| SCHEMBL3113026 | 0.84 | KMO (0.63) | KMOCPA1CPA3CPB1CPB2 | |
| SCHEMBL9554501 | 0.84 | KMO (0.72) | KMOCPA1CPA3CPB1CPB2 | |
| SCHEMBL7319589 | 0.84 | KMO (0.72) | KMOCPA1CPA3CPB1CPB2 | |
| SCHEMBL6672055 | 0.84 | KMT2A (0.50) | KMOPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214659-B1 | USE OF 4-OXOBUTANOIC ACID DERIVATIVES IN THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH IMMUNOLOGICAL DISORDERS | MERCK PATENT GMBH (DE) | 2011-08-31 | — | — | EP | disclosed |