Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675156 | 0.94 | NPC1 (0.53) | KMT2AKMONPC1RAB9ALMNA | |
| SCHEMBL3110072 | 0.92 | LDHA (0.54) | KMT2AKMONPC1RAB9APPARG | |
| SCHEMBL6672057 | 0.91 | NPC1 (0.46) | KMT2AMEN1ATMNPC1RAB9A | |
| SCHEMBL6662270 | 0.89 | KMT2A (0.48) | KMT2AMEN1ATMKMONPC1 | |
| SCHEMBL16284887 | 0.88 | NPC1 (0.60) | KMT2AKMONPC1RAB9AMAPT | |
| SCHEMBL6672877 | 0.88 | NPC1 (0.60) | KMT2AKMONPC1RAB9AMAPT | |
| SCHEMBL3101828 | 0.88 | NPC1 (0.60) | KMT2AKMONPC1RAB9AMAPT | |
| SCHEMBL16284888 | 0.88 | NPC1 (0.60) | KMT2AKMONPC1RAB9AMAPT | |
| SCHEMBL6670996 | 0.88 | ALDH1A1 (0.51) | KMT2AMEN1KMORAB9ALMNA | |
| SCHEMBL6675163 | 0.85 | NPC1 (0.51) | KMT2AMEN1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458412-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN ALPHA-GLUCOSIDASE INHIBITOR AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES | MERCK PATENT GmbH (DE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055523-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN ALPHA-GLUCOSIDASE INHIBITOR AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES | MERCK PATENT GMBH (DE) | 2003-07-10 | — | — | WO | disclosed |