Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14565994 | 0.87 | CTRC (0.50) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL8408945 | 0.85 | MAPT (0.45) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL8406995 | 0.82 | SMN1; SMN2 (0.42) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL14159647 | 0.80 | CTRC (0.53) | CTRCPPARGPTGESALOX5PPARA | |
| SCHEMBL9353141 | 0.79 | HSD17B10 (0.42) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL30639267 | 0.78 | CTRC (0.54) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL14484236 | 0.78 | L3MBTL1 (0.39) | MEN1KMT2ATDP1PPARGPTGES | |
| SCHEMBL10743959 | 0.76 | PPARG (0.42) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL11521450 | 0.76 | KMT2A (0.53) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL22680777 | 0.75 | ALOX15 (0.40) | MEN1NR1I2LMNACHRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173748-B1 | INDOLYL PYRROLIDINES FOR THE TREATMENT OF CANCER | ARQULE INC (US) | 2011-08-31 | — | — | EP | disclosed |