SCHEMBL2347739

SCHEMBL2347739

Cn1cc(C(=O)O)c(C(F)(Cl)Cl)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.47
LMNA P02545 2/20 0.46
POLB P06746 1/20 0.46
KMT2A Q03164 2/20 0.33
PKM P14618 2/20 0.33
MEN1 O00255 1/20 0.33
ABCC4 O15439 1/20 0.33
PTGS1 P23219 1/20 0.33
STING1 Q86WV6 1/20 0.32
TEAD1 P28347 1/20 0.32
TEAD4 Q15561 1/20 0.32
TEAD2 Q15562 1/20 0.32
TEAD3 Q99594 1/20 0.32
PLA2G7 Q13093 1/20 0.32
MGLL Q99685 1/20 0.32
ABHD6 Q9BV23 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
MAPK1 P28482 1/20 0.31
PSEN1 P49768 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2903444 0.90 LMNA (0.46) GAALMNAPOLBKMT2APKM
SCHEMBL2342441 0.86 GAA (0.47) GAALMNAPOLBSTING1MGLL
SCHEMBL5720264 0.86 POLB (0.41) GAALMNAPOLBKMT2ARAB9A
SCHEMBL19182678 0.86 GAA (0.56) GAALMNAPOLBPKMSTING1
SCHEMBL353314 0.86 GAA (0.56) GAALMNAPOLBPKMSTING1
Hydrochloric Acid SCHEMBL8355477 0.84 GAA (0.55) GAALMNAPOLBPKMSTING1
SCHEMBL1194663 0.83 LMNA (0.46) GAALMNAPOLBPKMSTING1
SCHEMBL1195430 0.81 LMNA (0.45) GAALMNAPOLBPKMSTING1
SCHEMBL773237 0.80 GRN (0.41) GAALMNAPOLBRAB9AGRN
SCHEMBL5274768 0.77 GAA (0.42) GAALMNAPOLBKMT2APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1856055-B1 PYRAZOLE CARBOXYLIC ACID ANILIDES, METHOD FOR THE PRODUCTION THEREOF AND AGENTS CONTAINING THEM FOR CONTROLLING PATHOGENIC FUNGI BASF SE (DE) 2014-10-01 EP disclosed
US-8008232-B2 Such as N-(3',4'-dichlorobiphenyl-2-yl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxamide; seeds BASF AKTIENGESELLSCHAFT (DE) 2011-08-30 US disclosed
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi BASF AKITENGESELLSCHAFT (DE) 2008-06-26 US disclosed
EP-1856055-A1 PYRAZOLE CARBOXYLIC ACID ANILIDES, METHOD FOR THE PRODUCTION THEREOF AND AGENTS CONTAINING THEM FOR CONTROLLING PATHOGENIC FUNGI BASF AKTIENGESELLSCHAFT (DE) 2007-11-21 EP disclosed
WO-2006087343-A1 PYRAZOLE CARBOXYLIC ACID ANILIDES, METHOD FOR THE PRODUCTION THEREOF AND AGENTS CONTAINING THEM FOR CONTROLLING PATHOGENIC FUNGI BASF AKTIENGESELLSCHAFT (DE) 2006-08-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi CBR3, C1S, PYM1 GAA 4672/4885LMNA 1073/4885POLB 2358/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.