Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | DAGLA | Q9Y4D2 | 4/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10132250 | 1.00 | CCR3 (0.47) | CCR3DAGLAABHD6APPHTR1A | |
| SCHEMBL10132334 | 0.89 | NPSR1 (0.50) | HCRTR1HCRTR2NPC1NR1H2NR1H3 | |
| SCHEMBL10132543 | 0.88 | KCNH2 (0.48) | ALOX5APFEN1NPC1NR1H2NR1H3 | |
| SCHEMBL1992474 | 0.88 | FPR3 (0.52) | NPC1NR1H2NR1H3 | |
| SCHEMBL1992473 | 0.88 | FPR3 (0.52) | NPC1NR1H2NR1H3 | |
| SCHEMBL10132293 | 0.88 | ALDH1A1 (0.51) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL698218 | 0.87 | NR1H2 (0.54) | DAGLAABHD6NR1H2NR1H3 | |
| SCHEMBL27854990 | 0.87 | NR1H2 (0.54) | DAGLAABHD6NR1H2NR1H3 | |
| SCHEMBL698422 | 0.87 | NR1H2 (0.54) | DAGLAABHD6NR1H2NR1H3 | |
| SCHEMBL10132355 | 0.87 | ALDH1A1 (0.46) | APPHTR1AADRA2ADRD2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113506-A1 | ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. (US) | 2021-06-10 | — | — | WO | disclosed |