Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23479912 | 0.99 | SIGMAR1 (0.48) | SIGMAR1ALOX15MEN1CYP3A4GAA | |
| SCHEMBL23479866 | 0.92 | ALOX15 (0.52) | SIGMAR1ALOX15MEN1CYP3A4GAA | |
| SCHEMBL23479890 | 0.91 | ALOX15 (0.50) | SIGMAR1ALOX15MEN1CYP3A4GAA | |
| SCHEMBL23479913 | 0.88 | KDM4E (0.41) | ALOX15MEN1GAAMAPTKMT2A | |
| SCHEMBL23479933 | 0.88 | TSHR (0.50) | CYP3A4MAPTKDM4EALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL23202498 | 0.87 | TSHR (0.49) | CYP3A4MAPTKMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL31096515 | 0.87 | TSHR (0.49) | CYP3A4MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL23479858 | 0.87 | L3MBTL1 (0.44) | SIGMAR1ALOX15GAAKDM4EHTT | |
| SCHEMBL23479882 | 0.83 | MAPK13 (0.47) | MEN1MAPTKMT2AKDM4EHTT | |
| SCHEMBL23479961 | 0.83 | KDM4E (0.42) | ALOX15MEN1CYP3A4GAACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION | 2021-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702403-B2 | EAAT2 activators and methods of using thereof | SLC1A2, SLC1A1, SLC18A2 | SIGMAR1 1142/4885ALOX15 1279/4885MEN1 4789/4885 |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | SIGMAR1 1142/4885ALOX15 1279/4885MEN1 4789/4885 |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | SIGMAR1 1142/4885ALOX15 1279/4885MEN1 4789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.