Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 9/20 | 0.48 |
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | DRD4 | P21917 | 8/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.44 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23482001 | 0.84 | HRH3 (0.60) | DRD3DRD2DRD4HRH3MEN1 | |
| SCHEMBL23481976 | 0.79 | METTL3 (0.51) | DRD3DRD4HRH3METTL3METTL14 | |
| SCHEMBL29965877 | 0.79 | METTL3 (0.51) | DRD3DRD4HRH3METTL3METTL14 | |
| SCHEMBL23458882 | 0.73 | DRD2 (0.49) | DRD3DRD2DRD4MEN1 | |
| SCHEMBL29919242 | 0.73 | DRD2 (0.49) | DRD3DRD2DRD4MEN1 | |
| SCHEMBL31519231 | 0.72 | DRD3 (0.64) | DRD3DRD2DRD4METTL3METTL14 | |
| SCHEMBL7442607 | 0.70 | DRD2 (0.51) | DRD3DRD2DRD4MEN1 | |
| SCHEMBL31663252 | 0.70 | DRD2 (0.51) | DRD3DRD2DRD4MEN1 | |
| SCHEMBL7503276 | 0.70 | DRD2 (0.51) | DRD3DRD2DRD4 | |
| SCHEMBL9056119 | 0.70 | DRD2 (0.51) | DRD3DRD2DRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11725010-B2 | Polyheterocyclic compounds as METTL3 inhibitors | STORM THERAPEUTICS LIMITED (GB) | 2023-08-15 | — | — | US | disclosed |
| US-11725010-B2 | Polyheterocyclic compounds as METTL3 inhibitors | STORM THERAPEUTICS LIMITED (GB) | 2023-08-15 | — | — | US | disclosed |
| US-20230002378-A1 | POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS | STORM THERAPEUTICS LIMITED (GB) | 2023-01-05 | — | — | US | disclosed |
| WO-2021111124-A1 | POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS | STORM THERAPEUTICS LIMITED (GB) | 2021-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002378-A1 | POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS | METTL3, DIMT1, TPMT | DRD3 2700/4885DRD2 4008/4885DRD4 3499/4885 |
| US-11725010-B2 | Polyheterocyclic compounds as METTL3 inhibitors | METTL3, DIMT1, TPMT | DRD3 2700/4885DRD2 4008/4885DRD4 3499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.